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IL1B Fibrosis Secretome Samples

ABSTRACT: Our results identify IL-1β induced immune-competency in human cardiac fibroblasts and suggest that fibroblast secretome modulation may constitute a therapeutic approach to PAH and other diseases typified by inflammation and fibrotic remodeling.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Fibroblast

DISEASE(S): Pulmonary Hypertension

SUBMITTER: Francesco Pagano

LAB HEAD: Jamila H Siamwala

PROVIDER: PXD044147 | Pride | 2024-01-26

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	1ml_Control.pdStudy	Other
	1ml_IL.pdStudy	Other
	Jamila_1ml_C_120919_10180501.msfView	Msf
	Jamila_1ml_C_120919_10180501.pdResult	Other
	Jamila_1ml_C_120919_10180501.pdResultView	Other

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1 - 5 of 15

Publications

IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling.

Siamwala Jamila H JH Pagano Francesco S FS Dubielecka Patrycja M PM Ivey Malina J MJ Guirao-Abad Jose Pedro JP Zhao Alexander A Chen Sonja S Granston Haley H Jeong Jae Yun JY Rounds Sharon S Kanisicak Onur O Sadayappan Sakthivel S Gilbert Richard J RJ

Communications biology 20231125 1

The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial hypertension (PAH) have been long debated. We demonstrate, using single-cell mass cytometry, a subpopulation of endogenous human cardiac fibroblasts expressing increased levels of CD4, a helper T-cell marker, in addition to myofibroblast markers distributed in human fibrotic RV tissue, interstitial and perivascular lesions in SUGEN/Hypoxia (SuHx) rats, and fi ...[more]

PMID: 38001239

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Expression data from IL-1β-stimulated immature human enterocytes treated with probiotic-conditioned media

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