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ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: siEYA4 pY IP-MS
The Eyes Absent family of proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour promoting across a range of cancer types. To date, the molecular targets of EYA phosphatase activity remain largely uncharacterised. Here, we identify Polo-like kinase 1 (PLK1) as ...
ORGANISM(S): Homo Sapiens (human) 
2024-02-26 | PXD036430 | Pride
Py ip Eya4 
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ProteomicsImmunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of epigenetic protein complexes has shown significant in vitro responses in acute myeloid leukemia (AML). Early clinical trials in KMT2A-rearranged leukemia indicate rather transient responses and development of resistance. In an effort to define functional dependencies of KMT...
ORGANISM(S): Homo Sapiens (human) 
2024-01-26 | PXD041245 | Pride
Aml Kmt2a Mll-fusion Leukemia Proteome Immunoproteasome 
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ProteomicsER-associated degradation of Eag1 potassium channels by the RING E3 ubiquitin ligase MKRN1: the presence of a dual ubiquitination system
Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K+ channel are associated with neurodevelopmental diseases, indicating an important role of Eag1 during brain development. A disease-causing Eag1 mutant channel is linked to defective protein stability that involves enhanced ...
ORGANISM(S): Homo Sapiens (human) 
2021-09-10 | PXD023984 | Pride
Ring e3 Mkrn1 
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ProteomicsMass spectrometry data of human urine
Based on UPLC-Q-TOF-MS metabolomics technology, urine samples of 1072 subjects from 9 centers, including normal control, phlegm and blood stasis (PBS) syndrome and Qi and Yin deficiency (QYD) syndrome, and other syndromes of CHD, were conducted to find biomarkers. Among them, the discovery set (n = 1...
ORGANISM(S): Homo Sapiens (human) 
2019-03-27 | PXD012910 | Pride
Urine Human Uplc-q/tof-ms 
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ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: EYA4 BioID
The aim of this project was to identify the EYA4 interactome. This was part of a larger research goal of identifying EYA4 phosphatase substrates and the cell biological consequences of their dephosphorylation.
ORGANISM(S): Homo Sapiens (human) 
2024-02-26 | PXD036405 | Pride
Bioid Eya4 
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UnknownKIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.
Not available
S-EPMC4962735 | biostudies-literature
0
ProteomicsThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation: PLK1 PRM
The aim of these experiments was to quantify PLK1 tyrosine phosphosites with respect to EYA4 and EYA1. PRM was performed on immunopurified PLK1. This was part of a larger project to characterize the effects of EYA4 mediated dephosphorylation on PLK1 functions.
ORGANISM(S): Homo Sapiens (human) 
2024-02-26 | PXD037064 | Pride
Plk1 prm 
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UnknownAssociation of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy.
Not available
S-EPMC3048137 | biostudies-literature
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UnknownRisk of Early Mortality in Patients With Newly Diagnosed Multiple Myeloma.
Not available
S-EPMC5058940 | biostudies-literature
0
UnknownRisk of Tuberculosis Among Patients on Dialysis: The Predictive Value of Serial Interferon-Gamma Release Assay.
Not available
S-EPMC4900731 | biostudies-literature
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