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ProteomicsProteomics approaches for decoding Plasmodium yoelii biology
Plasmodium yoelii is a rodent parasite commonly used as a model to study liver-stage development in host system during malaria infection. Mass spectrometry-based proteomics approaches helps in understanding the proteomic profiling of parasite and provided opportunities to explore the mechanisms contr...
ORGANISM(S): Plasmodium Yoelii Yoelii 17xnl Mus Musculus (mouse) 
2022-04-01 | PXD013932 | Pride
Post-translational modifications Proteomics Plasmodium yoelii 
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ProteomicsQuantitative proteomics identifies Yashtimadhu as a neuroprotectant against rotenone induced cellular model of Parkinson’s disease
We aimed to explore the neuroprotective efficacy of Yashtimadhu powder, prepared from the roots of Glycyrrhiza glabra L. (https://mpns.science.kew.org; http://www.ayurveda.hu/api/API-Vol-1.pdf) commonly known as licorice, a known Medhya rasayana in the Indian Ayurvedic texts against Parkinson’s diseas...
ORGANISM(S): Homo Sapiens (human) 
2021-09-09 | PXD019672 | Pride
Neuroprotection Complementary medicine Ayurveda Cellular stress Mitochondrial dysfunction Neurodegeneration Parkinson’s disease 
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ProteomicsProteomic profiling of murine melanoma treated with bone morphogenetic protein (BMP) signaling inhibitor
Melanoma is a highly aggressive skin cancer, which has the fastest and second fastest growing incidence of any cancer in men and women, respectively. Although melanoma accounts for 5% of skin cancers, it is responsible for 80% of deaths related to skin cancers. The lifetime risk of melanoma is curren...
ORGANISM(S): Mus Musculus (mouse) 
2022-02-15 | PXD016088 | Pride
Brplc Mouse Melanoma Protein profiling Skin Cancer 
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ProteomicsSILAC-based quantitative tyrosine phosphoproteomic profiling identifies alternative therapeutic targets to erlotinib in head and neck squamous cell carcinoma
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resista...
ORGANISM(S): Homo Sapiens (human) 
2022-10-13 | PXD007769 | Pride
Signaling pathways Quantitative proteomics Head and neck cancer Mass spectrometry Egfr-tyrosine kinase inhibitor resistance 
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ProteomicsDeep proteomic analysis of human hippocampus micro-sections provides a new avenue to identify hippocampal subfield heterogeneity in the protein expression
Hippocampus has drawn an immense attention from researchers and clinicians worldwide due to its clinical importance in various neurodegenerative disorders. Each hippocampal subfield is known to perform distinct functions and are selectively vulnerable to environmental, physiological, and clinical fac...
ORGANISM(S): Homo Sapiens (human) 
2022-10-14 | PXD029697 | Pride
Immunohistochemistry Spliceosome Dentate gyrus Coronu ammonis Subfields Manual-microdissection Formalin fixed paraffin embedded tissue 
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ProteomicsGenetic aberrations in MAP kinase pathway play an important role in erlotinib resistance in head and neck cancer
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resista...
ORGANISM(S): Homo Sapiens (human) 
2019-12-18 | PXD007785 | Pride
Signaling pathways Head and neck cancer Quantitative phosphoproteomics Mass spectrometry Egfr-tyrosine kinase inhibitor resistance 
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ProteomicsSILAC-based proteomic approach to delineate molecular alterations associated with erlotinib resistance in head and neck squamous cell carcinoma
Although Epidermal growth factor receptor (EGFR) is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted small molecule inhibitors such as erlotinib have shown a modest activity in recurrent or advanced HNSCC. To investigate the acquired m...
ORGANISM(S): Homo Sapiens (human) 
2019-12-18 | PXD007768 | Pride
Signaling pathways Quantitative proteomics Head and neck cancer Mass spectrometry Egfr-tyrosine kinase inhibitor resistance 
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Transcriptomics26G endo-siRNAs regulate spermatogenic and zygotic gene expression
Analysis of small RNAs with 5'p, 3'OH Small RNAs (18-32nt) expressed in purified male sperm, hermaphrodite oocytes, embryos, N2, glp-4(bn2), and eri-1(mg366) were cloned and sequenced by 454 and Illumina high-throughput sequencing.
ORGANISM(S): Caenorhabditis elegans 
2010-05-24 | E-GEOD-20341 | biostudies-arrayexpress
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UnknownEvaluation of reinforced plication as an alternative to resection in exotropia.
Not available
S-EPMC9114539 | biostudies-literature
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ProteomicsAspergillus fumigatus melanin manipulates the cargo and kinetics of neutrophil-derived extracellular vesicles
Neutrophil-derived extracellular vesicles have regained scientific interest as potent ‘wireless’ modulators with pleiotropic effects on the immune system. A few studies have addressed their role in the context of microbial pathogenesis showing their bacteriostatic effects against Staphylococcus aureu...
ORGANISM(S): Neosartorya Fumigata (aspergillus Fumigatus) 
2019-05-17 | PXD005994 | Pride
Antifungal extracellular vesicles Neutrophils Aspergillus fumigatus Melanin 
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