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ProteomicsAutophagy the key player in trabecular meshwork death-mechanistic difference in early and advanced glaucoma
This study highlights the differential roles of apoptosis versus autophagy in cell death mechanism in the trabecular meshwork in primary adult glaucoma at various stages. This reflects the possible role of autophagy in causing glaucomatous damage in severe disease stages
ORGANISM(S): Homo Sapiens (human) 
2021-09-08 | PXD010752 | Pride
Glaucoma Pacg Trabecular meshwork Poag Proteomics Autophagy 
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ProteomicsImpact of neonatal lead exposure on memory: A study highlighting the association between hippocampal synaptic proteome and cognitive decline in rats
Lead (Pb2+) is a heavy metal ubiquitously present in the environment, with unknown essential functions to sustain life. The detrimental effects of Pb2+ on health are known since ancient times, which is also well supported by scientific literature. Incidentally, Pb2+ toxicity is more severe in childre...
ORGANISM(S): Rattus Norvegicus (rat) 
2023-03-10 | PXD034212 | Pride
Memory impairment Lead toxicity Proteomics Hippocampus 
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ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (bRaf mutated)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (bRaf mutated) Crosstalk model of the ERK, Wnt and Akt signalling pathways with bRaf mutation This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network constituti...
2024-09-02 | BIOMD0000000653 | BioModels
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ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (EGFR overexpression)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (EGFR overexpression) Crosstalk model of the ERK, Wnt and Akt signalling pathways with EGFR overexpression. This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network ...
2024-09-02 | BIOMD0000000656 | BioModels
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ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (PI3K mutated)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (PI3K mutated) Crosstalk model of the ERK, Wnt and Akt signalling pathways with mutated PI3K. This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network constituti...
2024-09-02 | BIOMD0000000652 | BioModels
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ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (normal)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (normal) Crosstalk model of the ERK, Wnt and Akt signalling pathways under normal condition. This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network constitutiv...
2024-09-02 | BIOMD0000000648 | BioModels
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ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (Ras mutated)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (Ras mutated) Crosstalk model of the ERK, Wnt and Akt signalling pathways with Ras mutation. This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network constitutiv...
2024-09-02 | BIOMD0000000654 | BioModels
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ModelsPadala2017- ERK, PI3K/Akt and Wnt signalling network (PTEN mutation)
Padala2017- ERK, PI3K/Akt and Wnt signalling network (PTEN mutation) Crosstalk model of the ERK, Wnt and Akt Signalling pathways with PTEN mutation. This model is described in the article: Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/?-catenin signaling network constitu...
2024-09-02 | BIOMD0000000655 | BioModels
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GenomicsBach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunction...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress
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GenomicsNHLBI Jackson Heart Study Candidate Gene Association Resource (CARe)

The Jackson Heart Study (JHS) is a large, community-based, observational study whose participants were recruited from urban and rural areas of the three counties (Hinds, Madison and Rankin) that make up the Jackson, Mississippi, metropolitan statistical area (MSA). Participants were enrolled fr...

phs000286.v2.p1 | EGA
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