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Metabolic rewiring is a well-established feature of muscle cells and a hallmark of cancer. In isocitrate dehydrogenase 1 and 2 mutant tumors, increased production of the oncometabolite D-2-hydroxyglutarate (D2-HG) is associated with myopathy. The connection between metabolic changes and proteomic rem...
ORGANISM(S): Mus Musculus (mouse) 
2024-08-10 | PXD022137 | Pride
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We comparatively analyzed survival and physiological adaptation of S. aureus HG001 to two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen´s proteome ...
ORGANISM(S): Staphylococcus Aureus 
2014-09-01 | PXD001003 | Pride
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This approach aims at searching unidentified regulatory roles of the AreB transcription factor in the overall carbon metabolism of A. niger. A full areB gene deletion mutant was constructed and characterized in A. niger ATCC 1015. Both strains were grown on glucose or glycerol using ammonia as nitrog...
ORGANISM(S): Aspergillus niger 
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Expression data from batch cultivations of Aspergillus niger wild type strain ATCC 1015 and adrA, facB and creA deletion mutants constructed on ATCC 1015 background strain with glucose or glycerol as carbon sources. Genome-wide transcriptome analysis was used to identify genes either affected directl...
ORGANISM(S): Aspergillus niger 
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