Proteomics

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Comparative analysis of the adaptation of Staphylococcus aureus to internalization by different types of human non-professional phagocytic host cells

ABSTRACT: We comparatively analyzed survival and physiological adaptation of S. aureus HG001 to two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria from host-pathogen assays by cell sorting and quantitation of the pathogen´s proteome by mass spectrometry we characterized S. aureus adaptation during the initial phase between 2.5 h and 6.5 h post-infection.

OTHER RELATED OMICS DATASETS IN: MTBLS102

INSTRUMENT(S): Q Exactive

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Maren Depke  

LAB HEAD: Frank Schmidt

PROVIDER: PXD001003 | Pride | 2014-09-01

REPOSITORIES: Pride

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Dataset's files

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Action DRS
1301028_FS_HPI_A549_BR1_OD_Null_vier_Sample1_rs.mzXML Mzxml
1301028_FS_HPI_A549_BR1_OD_Null_vier_Sample1_rs.pep.xml Pepxml
13030_FS_HPI_HEK_BR1_OD_Null_vier_Sample25_rs.mzXML Mzxml
13030_FS_HPI_HEK_BR1_OD_Null_vier_Sample25_rs.pep.xml Pepxml
130326_FS_HPI_A549_BR1_ssechseinhalb_h_Sample4_rs.mzXML Mzxml
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Comparative proteome analysis reveals conserved and specific adaptation patterns of Staphylococcus aureus after internalization by different types of human non-professional phagocytic host cells.

Surmann Kristin K   Michalik Stephan S   Hildebrandt Petra P   Gierok Philipp P   Depke Maren M   Brinkmann Lars L   Bernhardt Jörg J   Salazar Manuela G MG   Sun Zhi Z   Shteynberg David D   Kusebauch Ulrike U   Moritz Robert L RL   Wollscheid Bernd B   Lalk Michael M   Völker Uwe U   Schmidt Frank F  

Frontiers in microbiology 20140801

Staphylococcus aureus is a human pathogen that can cause a wide range of diseases. Although formerly regarded as extracellular pathogen, it has been shown that S. aureus can also be internalized by host cells and persist within these cells. In the present study, we comparatively analyzed survival and physiological adaptation of S. aureus HG001 after internalization by two human lung epithelial cell lines (S9 and A549), and human embryonic kidney cells (HEK 293). Combining enrichment of bacteria  ...[more]

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