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ProteomicsBcl11b depleted and IL-15 stimulated αβ CD8+ T cells acquire a unique innate-like phenotype and are highly functional
Loss of BCL11B in human peripheral blood CD8+ T cells led to acquisition of an innate-like phenotype and the ability to efficiently lyse tumor cells either spontaneously via the NKp30/B7H6 axis or mediated by a GD2 antibody. The phenotype of BCL11B knock-out cells was investigated by characterization...
ORGANISM(S): Homo Sapiens (human) 
2022-12-13 | PXD033542 | Pride
Cd8+ t cells Bcl11b knock-out Bcl11b Il-15 Innateness 
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GenomicsSARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes [10x]
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding,...
EGAS00001005060 | EGA
COVID-19 SARS-CoV-2 2019 novel coronavirus infection 2019-nCoV infection severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 SARS-coronavirus 2 
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Genomics5c638551-978c-4e80-b87e-d669d6b7069e - samples
Full information about the T cell receptor (CR) variable regions found in the sequences of the vdj region. Columns: barcode is_cell contig_id high_confidence length chain v_gene d_gene j_gene c_gene full_length productive cdr3 cdr3_nt reads umis raw_clonotype_id raw_consensus_id
EGAD00001008109 | EGA
COVID-19 SARS-CoV-2 2019 novel coronavirus infection 2019-nCoV infection severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 SARS-coronavirus 2 
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Genomics5a9f4bd6-d795-47e9-9690-979bf5b1df6b - samples
The data contains single-cell gene sequencing data (10x Genomics) from FACS-purified CD8 T lymphocytes from two Austrian patients. The cells were stimulated with one MHC class I peptides obtained from a common (wild type) variant and an emerging mutant variant of the SARS-Cov-2 virus. Then the sampl...
EGAD00001006995 | EGA
COVID-19 SARS-CoV-2 2019 novel coronavirus infection 2019-nCoV infection severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 SARS-coronavirus 2 
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ProteomicsDnmt1 has de novo activity targeted to transposable elements
DNA methylation plays a critical role in development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b. Here we demonstrate that Dnmt1 displays de novo...
ORGANISM(S): Mus Musculus (mouse) 
2021-06-29 | PXD025736 | Pride
Dnmt1 Retrotransposon Dna methylation Uhrf1 
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TranscriptomicsGene expression of resting memory, resting naive and in vitro activated memory CD8+CD127+ T cells from spleen and bone marrow (BM)
To understand differences between resting and activated memory CD8+ T cells, we compared the global gene expression of ex vivo isolated naive and spleen and BM memory cells to in vitro activated spleen and BM memory cells. Single cell suspension from the spleen and bones of aged C57BL/6 mice were pre...
ORGANISM(S): Mus musculus 
2015-02-05 | E-GEOD-62691 | biostudies-arrayexpress
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ProteomicsProximity biotinylation and LC-MSMS identification of the molecular microenvironment of coronavirus replication complexes
To investigate virus-host interactions at the site of coronavirus replication, we developed a biotin-based proximity labelling approach by engineering a promiscuous biotin ligase, BirA-R118G, within the coronavirus replication and transcription complex (RTC). BirA-R118G was fused to non-structural pr...
ORGANISM(S): Murine Hepatitis Virus Strain A59 Mus Musculus (mouse) 
2019-01-16 | PXD009975 | Pride
L929 mouse fibroblast Bira-r118g Bioid Lc-msms Viral replication complex Mouse hepatitis virus 
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TranscriptomicsExpression data from Human CD40L+ Tcells
To assess the nature of CD8+CD40L+ memory Tcells, we compared the gene expression to CD8+CD40L- and CD4+ counterparts, and found similarities in expression of genes encoding cytokines PBMCs were isolated from five healthy donors. The cells were stimulated with PMA/Ionomycin for 6 h, and subsequently ...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-GEOD-44126 | biostudies-arrayexpress
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GenomicsCCRI COVID Patient Data Access Committee
Data Access Committee EGAC00001001989
EGAC00001001989 | EGA
0
UnknownUnderstanding Thiel embalming in pig kidneys to develop a new circulation model.
Not available
S-EPMC4373718 | biostudies-literature
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