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ProteomicsProteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
Resistance to proteasome inhibitors (PIs) is a ubiquitous clinical concern in multiple myeloma. We proposed that signaling-level responses after PI would reveal new means to enhance efficacy. Unbiased phosphoproteomics after the PI carfilzomib surprisingly demonstrated the most prominent phosphoryl...
ORGANISM(S): Homo Sapiens (human) 
2020-02-21 | PXD012172 | Pride
Spliceosome Alternative splicing Splice factor Splicing Proteasome inhibition Multiple myeloma Lc-msms phosphoproteomics Cancer 
0
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues from ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
1K
OtherUK10K project
...tter understand the link between low-frequency and rare genetic changes, and human disease caused by harmful changes to the proteins the body makes. Although many hundre...
...efore. Please note that a publication moratorium is in place to protect the first publication rights of UK10K sample custodians and data generators. This moratorium will expire on 02 July 201...
EGAO00000000079 | EGA
1K
OtherKOL
Organisation EGAO00000000902
EGAO00000000902 | EGA
1K
OtherKolling Institute of Medical Research
Organisation EGAO00000000903
EGAO00000000903 | EGA
0
GenomicsMulti-Ethnic Study of Atherosclerosis (MESA) Cohort

MESA
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristi...
...lar disease or progression of the subclinical disease. MESA researchers study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-84. Thirty-eight percent of the recruited particip...

phs000209.v10.p2 | EGA
0
Genomics,MultiomicsAbundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

In this paper (Gibbs et al., 2010, PMID: 20485568) we ...
...studied the cerebellum, frontal cortex, temporal cortex and pons regions of 150 individuals (600 tissue samples). In each tissue we assessed 27,57...

phs000249.v1.p1 | EGA
1K
OtherOICR_ICGC
Organisation EGAO00000000099
EGAO00000000099 | EGA
0
GenomicsNHLBI Family Heart Study (FamHS-Visit1 and FamHS-Visit2)

The Family Heart Study (FamHS) was funded by the National Heart, Lung, and Blood Institute (NHLBI). It was begun in 1992 with the ascertainment of 1,200 families, half randomly sampled, and half selected because of an excess of coronary heart disease (CHD) or risk factor abnormalities as compared ...

phs000221.v1.p1 | EGA
1K
OtherBritish Columbia Cancer Agency (BCCA), Genome Sciences Centre
The mandate of the Genome Sciences Centre at BCCA is to advance knowledge about cancer and other diseases, to improve human health through disease prevention, diagnosis and therapeutic approaches, and to realize the social and economical benefits of genomics and informatics research
EGAO00000000002 | EGA
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