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Omics score: 1004

British Columbia Cancer Agency (BCCA), Genome Sciences Centre

ABSTRACT: The mandate of the Genome Sciences Centre at BCCA is to advance knowledge about cancer and other diseases, to improve human health through disease prevention, diagnosis and therapeutic approaches, and to realize the social and economical benefits of genomics and informatics research

PROVIDER: EGAO00000000002 | EGA |

REPOSITORIES: EGA

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Publications

MEN1 mutations in Hürthle cell (oncocytic) thyroid carcinoma.

Kasaian Katayoon K Chindris Ana-Maria AM Wiseman Sam M SM Mungall Karen L KL Zeng Thomas T Tse Kane K Schein Jacqueline E JE Rivera Michael M Necela Brian M BM Kachergus Jennifer M JM Casler John D JD Mungall Andrew J AJ Moore Richard A RA Marra Marco A MA Copland John A JA Thompson E Aubrey EA Smallridge Robert C RC Jones Steven J M SJ

The Journal of clinical endocrinology and metabolism 20150127 4

<h4>Context and objective</h4>Oncocytic thyroid carcinoma, also known as Hürthle cell thyroid carcinoma, accounts for only a small percentage of all thyroid cancers. However, this malignancy often presents at an advanced stage and poses unique challenges to patients and clinicians. Surgical resection of the tumor accompanied in some cases by radioactive iodine treatment, radiation, and chemotherapy are the established modes of therapy. Knowledge of the perturbed oncogenic pathways can provide be ...[more]

PMID: 25625803

Publication: 1/13

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British Columbia Cancer Agency (BCCA), Ovarian Cancer Research

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Magnetotactic bacteria from Pavilion Lake, British Columbia.

Project description:Pavilion Lake is a slightly alkaline, freshwater lake located in British Columbia, Canada (50°51'N, 121°44'W). It is known for unusual organosedimentary structures, called microbialites that are found along the lake basin. These deposits are complex associations of fossilized microbial communities and detrital- or chemical-sedimentary rocks. During the summer, a sediment sample was collected from near the lake's shore, approximately 25-50 cm below the water surface. Magnetotactic bacteria (MTB) were isolated from this sample using a simple magnetic enrichment protocol. The MTB isolated from Pavilion Lake belonged to the Alphaproteobacteria class as determined by nucleotide sequences of 16S rRNA genes. Transmission electron microscopy (TEM) revealed that the bacteria were spirillum-shaped and contained a single chain of cuboctahedral-shaped magnetite (Fe3O4) crystals that were approximately 40 nm in diameter. This discovery of MTB in Pavilion Lake offers an opportunity to better understand the diversity of MTB habitats, the geobiological function of MTB in unique freshwater ecosystems, and search for magnetofossils contained within the lake's microbialites.

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British Columbia Cancer Agency (BCCA) PHSAs Technology Development Office, Data Access Committee

Project description:Data Access Committee EGAC00001002968

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British Columbia Cancer Agency (BCCA), PHSAs Technology Development Office, Data Access Committee

Project description:Data Access Committee EGAC00001002903

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Exploring vaccination practices of midwives in British Columbia.

Project description:BackgroundRegistered midwives in British Columbia (BC) are primary health care practitioners for healthy people throughout pregnancy and for approximately 6 weeks postpartum. BC registered midwives are authorized to prescribe and administer certain vaccines to adults under their care during the perinatal period and hepatitis B vaccine to high-risk newborns. However, little has been documented about their recommendations for, and administration of, prenatal and infant vaccinations. This study surveyed midwives currently practicing in British Columbia to understand their vaccination practices.MethodsAn online survey was administered to the members of the Midwives Association of BC in spring 2018. Outcome measures were the proportion of midwives who discussed, recommended, and administered the following vaccines: influenza, varicella, rubella, and infant hepatitis B. The proportion of midwives who discussed and recommended infant vaccines was measured. Barriers to discussion, recommendation, and administration of vaccines were captured.ResultsSixty-three percent of 108 respondents administered vaccines to their clients. Hepatitis B and rubella were the most frequent vaccines administered. Logistical concerns were the greatest barrier to vaccine administration. This was followed by the perception that vaccine administration is not within the scope of practice of midwives, especially for influenza vaccine. Midwives who administered vaccines were significantly more likely to discuss and recommend vaccines to their clients and their infants.ConclusionsThe majority of BC midwives discuss, recommend, and administer vaccines to their clients. Our survey highlighted key areas to address to strengthen midwifery capacity to discuss, recommend, and provide prenatal and infant vaccines.

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Novel avian influenza H7N3 strain outbreak, British Columbia.

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DAC: British Columbia Cancer Agency (BCCA), PHSAs Technology Development Office, Data Access Committee

Project description:Data Access Committee EGAC00001000122

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