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ProteomicsProteomic profiles of control, AUF1-overexpressed, and CVB3-infected HeLa cells
...AUF1 on downstream molecules stabilities and transcriptions. In our work, iTRAQ approach was firstly used to quantitatively identify differentially expressed cellular proteins in AUF1-overexpressed HeLa cells, which would provide us a new insight into the role of AUF1 on cellular progress. We identi...
ORGANISM(S): Homo Sapiens (human) 
2023-03-10 | PXD021094 | Pride
Lc-ms Auf1 Lysate Human hela cells 
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ProteomicsModeling CRL4A ligase complex to predict target protein ubiquitination induced by CRBN-recruiting PROTACs
...is TArgeting Chimeras (PROTACs) are bifunctional small molecules that can simultaneously recruit target protein and E3 ligase to form a ternary complex (target protein / PROTAC / E3 ligase), leading to target protein ubiquitination and degradation via the Ubiquitin-Proteasome System (UPS). PROTACs ha...
ORGANISM(S): Homo Sapiens (human) 
2022-05-19 | PXD030213 | Pride
Ubiqutination Protac Tmt 
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ProteomicsHDX-MS of NicA2 and a NicA2 variant with increased activity
Here we have used HDX-MS to investigate the change in structure/dynamics in NicA2 and a variant with increased activity (v321) that was generated using directed evolution
ORGANISM(S): Homo Sapiens (human) 
2023-11-16 | PXD037151 | Pride
Directed evolution Nica2 Nicotine oxidoreductase 
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