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Proteomics,MultiomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 5 populations ex vivo
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins ...
ORGANISM(S): Homo Sapiens (human) 
2018-05-18 | PXD005477 | Pride
Human Lfq Cd4+ t cells 
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Proteomics,MultiomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 6 populations ex vivo
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins ...
ORGANISM(S): Homo Sapiens (human) 
2018-05-18 | PXD007744 | Pride
Human Cd4+ t lymphocyte Blood 
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ProteomicsIdentification of NPGPx-interacting proteins in activated T cells
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholip...
ORGANISM(S): Homo Sapiens (human) 
2021-01-25 | PXD017046 | Pride
Zap70 Npgpx T cell activation 
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Proteomics,MultiomicsQuantitative Proteomics Reveals Specialized Wiring of Signaling Pathways that Protects Human Regulatory T Cell Identity - 2 populations in vitro
Regulatory CD4+ T cells (Tregs) are functionally distinct from conventional CD4+ T cells (Tconvs). To understand Treg identity, we compared by proteomics and transcriptomics human naïve (n) and effector (e)Tregs, Tconvs and transitional FOXP3+ cells. Only 12% of 422 differentially expressed proteins ...
ORGANISM(S): Homo Sapiens (human) 
2018-05-18 | PXD007745 | Pride
Human Cd4+ t lymphocytes Blood 
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ProteomicsIdentification of the intermolecular disulfide bonds between NPGPx and ZAP70
The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we showed that deficiency of non-selenocysteine containing phospholip...
ORGANISM(S): Homo Sapiens (human) 
2021-01-25 | PXD017034 | Pride
Zap70 Npgpx Disulfide bond 
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GenomicsExome Sequencing for Diseases of the Immune System: X-linked Immunodeficiency with Magnesium Defect, EBV Infection, and Neoplasia (XMEN)

The etiologies of primary immunodeficiencies often yield novel insights about the immune system. Although a genetic etiology has been suspected for patients with abnormally low CD4+ T cells in the absence of HIV infection or any known causes of lymphopenia, no genetic mutation has been des...

phs000365.v1.p1 | EGA
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TranscriptomicsTranscription profiling of human non anaplastic T-cell lymphoma
A ﾑCartes dﾒIdentite des Tumeursﾒ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 17 AITL biopsies, 2 AITL sorted cells, 16 PTCL NOS biopsies | The molecular alterations underlying the pathogenesis of angioimmunoblasti...
ORGANISM(S): Homo sapiens 
2009-09-22 | E-TABM-783 | biostudies-arrayexpress
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TranscriptomicsCD8+ T cell gene expression after different antigen dose stimulations
This study aimed to identify the human T cell response toward different antigen doses. Fresh isolated CD8+ T cells from peripheral blood mononuclear cells (PBMCs) were stimulated with influenza M1 peptide-loaded autologous monocyte-derived dendritic cells for 2 weeks. A high M1 peptide antigen dose (...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-39761 | biostudies-arrayexpress
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ProteomicsMitochondrial ATP generation is more proteome efficient than glycolysis (M. musculus)
Metabolic efficiency profoundly influences organismal fitness. Heterotrophs, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. While respiration is more energy-efficient, some cells favor glycolysis even when oxygen is available (aerobic glycolysis, Warburg eff...
ORGANISM(S): Mus Musculus (mouse) 
2024-04-25 | PXD048041 | Pride
Mus musculus Orbitrap fusion lumos Absolute proteomics 
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ProteomicsMitochondrial ATP generation is more proteome efficient than glycolysis (I. orientalis)
Metabolic efficiency profoundly influences organismal fitness. Heterotrophs, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. While respiration is more energy-efficient, some cells favor glycolysis even when oxygen is available (aerobic glycolysis, Warburg eff...
ORGANISM(S): Pichia Kudriavzevii 
2024-04-25 | PXD048012 | Pride
Issatchenkia orientalis Orbitrap fusion lumos Absolute proteomics 
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