Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-2154

ABSTRACT: Transcription profiling time series of mouse embryonic chondrocyte differentiation

OTHER RELATED OMICS DATASETS IN: PRJNA91417

PROVIDER: E-GEOD-2154 | ExpressionAtlas | 2014-08-15

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-2154-analysis-methods.tsv	Tabular
	E-GEOD-2154-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-2154-configuration.xml	Xml
	E-GEOD-2154-percentile-ranks.tsv	Tabular
	E-GEOD-2154.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 115

Similar Datasets

Dynamic proteomic profiling of extra-embryonic endoderm differentiation in mouse embryonic stem cells

Project description:During mammalian pre-implantation development, the cells of the blastocyst’s inner cell mass differentiate into the epiblast and primitive endoderm lineages, which give rise to the fetus and extra-embryonic tissues, respectively. Extra-embryonic endoderm differentiation can be modeled in vitro by induced expression of GATA transcription factors in mouse embryonic stem cells. Here we use this GATA-inducible system to quantitatively monitor the dynamics of global proteomic changes during the early stages of this differentiation event and also investigate the fully differentiated phenotype, as represented by embryo-derived extra-embryonic endoderm (XEN) cells. Using mass spectrometry-based quantitative proteomic profiling with multivariate data analysis tools, we reproducibly quantified 2,336 proteins across three biological replicates and have identified clusters of proteins characterized by distinct, dynamic temporal abundance profiles. We first used this approach to highlight novel marker candidates of the pluripotent state and extra-embryonic endoderm differentiation. Through functional annotation enrichment analysis, we have shown that the downregulation of chromatin-modifying enzymes, the re-organization of membrane trafficking machinery and the breakdown of cell-cell adhesion are successive steps of the extra-embryonic differentiation process. Thus, applying a range of sophisticated clustering approaches to a time-resolved proteomic dataset has allowed the elucidation of complex biological processes which characterize stem cell differentiation and could establish a general paradigm for the investigation of these processes.

2015-06-13 | PXD001901 | Pride

Transcription Pausing Regulates Mouse Embryonic Stem Cell Differentiation

Project description:Transcription Pausing Regulates Mouse Embryonic Stem Cell Differentiation

| PRJNA389555 | ENA

Drosophila erecta

Project description:Drosophila erecta embryonic development RAMPAGE time series

| PRJNA351835 | ENA

Drosophila species embryonic development RAMPAGE time series

Project description:Drosophila species embryonic development RAMPAGE time series

| PRJNA351836 | ENA

Drosophila ananassae

Project description:Drosophila ananassae embryonic development RAMPAGE time series

| PRJNA351809 | ENA

Drosophila pseudoobscura

Project description:Drosophila pseudoobscura embryonic development RAMPAGE time series

| PRJNA351829 | ENA

Drosophila simulans

Project description:Drosophila simulans embryonic development RAMPAGE time series

| PRJNA351832 | ENA

Homo sapiens

Project description:FM95-14 Fetal Myoblast Differentiation Time Series

| PRJNA93973 | ENA

MAP-Proteome Quantification Tool mESC proteomics Data

Project description:The iTRAQ dataset for mouse embryonic stem cell differentiation.

2018-05-19 | MSV000082375 | MassIVE

Mus musculus

Project description:Mouse Pancreatic Islet Maturation Time Series

| PRJNA348543 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data