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E-MEXP-1717

ABSTRACT: Transcription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series

PROVIDER: E-MEXP-1717 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-MEXP-1717-analysis-methods.tsv	Tabular
	E-MEXP-1717-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-1717-configuration.xml	Xml
	E-MEXP-1717-percentile-ranks.tsv	Tabular
	E-MEXP-1717.condensed-sdrf.tsv	Tabular

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Transcription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series

Project description:Theilers murine encephalomyelitis (TME) is an experimentally virus-induced demyelinating leukomyelitis, displaying clinical and pathological similarities to chronic progressive multiple sclerosis. <br>The aim of this study was to identify pathways associated with demyelination using an assumption-free microarray approach. <br>Five-week-old female SJL/JHanHsd-mice were intracerebrally infected with the BeAn-strain of the TME- virus (TMEV) or mock-infected with vehicle only.<br>Groups of 5-6 TMEV- and Mock-infected mice were killed at 14, 42, 98, and 196 days post infection.<br>Total RNA was isolated from the spinal cords and gene expression was measured employing Affymetrix mouse genome 430 2.0 arrays.

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