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E-GEOD-40827

ABSTRACT: SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

PROVIDER: E-GEOD-40827 | ExpressionAtlas | 2020-03-31

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-40827-analysis-methods.tsv	Tabular
	E-GEOD-40827-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-40827-configuration.xml	Xml
	E-GEOD-40827-percentile-ranks.tsv	Tabular
	E-GEOD-40827.condensed-sdrf.tsv	Tabular

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SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

Project description:Comparing the host response of C57BL/6J mice to KEPI (ppp1r14c) knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or KEPI (ppp1r14c) knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40827 | biostudies-arrayexpress

SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40824 | biostudies-arrayexpress

SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40840 | biostudies-arrayexpress

Mus musculus

Project description:SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

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Mus musculus

Project description:SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

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E-GEOD-40840

Project description:SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

2020-03-31 | E-GEOD-40840 | ExpressionAtlas

SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.

Project description:Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.

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SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.

Project description:Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection. Twenty-week-old C57BL/6 mice were infected by intranasal instillation of 10^2, 10^3, 10^4 or 10^5 PFU of SARS CoV MA15 in 50 µl of PBS or mock-infected with PBS alone. At days 1, 2, 4 and 7 days post-infection, lungs were harvested and total RNA was isolated and subjected to microarray analysis. The experimental design was for 4- 5 mice/time point/dose and 3 time-matched mocks. The NIAID Systems Virology Center

2011-11-01 | E-GEOD-33266 | biostudies-arrayexpress

Mus musculus

Project description:SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

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E-GEOD-40824

Project description:SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

2020-03-31 | E-GEOD-40824 | ExpressionAtlas