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E-GEOD-49998

ABSTRACT: Gene Level Expression Profiling: Activity dependent genes in the olfactory epithelium

OTHER RELATED OMICS DATASETS IN: PRJNA215768

PROVIDER: E-GEOD-49998 | ExpressionAtlas | 2015-07-27

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-49998-analysis-methods.tsv	Tabular
	E-GEOD-49998-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-49998-configuration.xml	Xml
	E-GEOD-49998-percentile-ranks.tsv	Tabular
	E-GEOD-49998.condensed-sdrf.tsv	Tabular

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Mus musculus

Project description:Gene Level Expression Profiling: Activity dependent genes in the olfactory epithelium

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Gene Level Expression Profiling: Activity dependent genes in the olfactory epithelium

2014-04-21 | GSE49998 | GEO

Gene Level Expression Profiling: Activity dependent genes in the olfactory epithelium

Project description:Gene level analysis of RNA samples from mice olfactory epithelium Gene expression profiling in the olfactory epithelium was performed to obtain a better understanding of the processes mediating activity dependent gene regulation We analyzed total RNA from olfactory epithelium tissue from 3 mice at 5 days following unilateral naris occlusion (NO) using the Affymetrix Mouse Exon 1.0 ST Array, comparing unilateral and ipsilateral epithelia.

2014-04-21 | E-GEOD-49998 | biostudies-arrayexpress

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Project description:Activity-dependent gene expression in the mammalian olfactory epithelium

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Exon Level Expression Profiling: Induced adult neurogenesis in the olfactory epithelium

Project description:Transcriptome analysis of RNA samples from mice olfactory epithelium Gene expression profiling in the olfactory epithelium was performed to obtain a better understanding of the processes mediating cell replacement.

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Mus musculus

Project description:Exon Level Expression Profiling: Induced adult neurogenesis in the olfactory epithelium

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Expression data from olfactory epithelium of Harlequin mutant mice compared to littermate controls

Project description:Microarray analysis of gene expression in the olfactory epithelium of Harlequin mouse as a model of oxidative-stress induced neurodegeneration of olfactory sensory neurons Keywords: comparison of gene expression level in unperturbed tissue of mutant vs. control mouse

2007-12-06 | GSE6485 | GEO

NFI transcription factors regulate zonal olfactory receptor expression

Project description:Expression of one out of > 1000 olfactory receptor (OR) genes is stochastic, yet organized into anatomic "zones" along the dorsoventral axis of the olfactory epithelium. Here we profile the gene expression, chromatin state and nuclear architecture of olfactory sensory neurons and olfactory progenitors of different zones. We discovered that zonal OR expression is specified by two processes: low-level polygenic transcription of OR genes in olfactory progenitors, as wells as the chromatin structure and nuclear architecture during olfactory differentiation. Specifically, in cells of any zonal segment, polygenic transcription in olfactory progenitors defines the OR repertoire eligible for OR choice as the cells mature, while an increased level of heterochromatin and chromatin compaction represses ectopic more dorsally expressed ORs. We find that this process is regulated by the NFI family of transcription factors that are expressed in a graded fashion in the olfactory epithelium. Conditional deletion of NFI A, B, and X results in a transformation of the chromatin state and nucellar architecture and an accompanying shift in the preferred OR repertoire.

2023-06-14 | GSE158730 | GEO

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

Project description:This SuperSeries is composed of the following subset Series: GSE39514: Effects of H2be ectopic over-expression on gene expression in the main olfactory epithelium (MOE) of 5-week old mice. GSE39515: Effects of H2be loss of function on gene expression in the main olfactory epithelium (MOE) of 6-month old mice. GSE39516: Effects of H2be loss of function on gene expression changes in the main olfactory epithelium (MOE) as a result of activity deprivation through unilateral naris occlusion (UNO). GSE39517: Genome-wide location analysis of FLAG-H2BE Refer to individual Series

2012-09-01 | E-GEOD-39674 | biostudies-arrayexpress

Cystic fibrosis causes olfactory system defects by altering progenitor cell proliferation (scRNA-Seq)

Project description:A reduced sense of smell has been reported in people with cystic fibrosis (CF). These olfactory defects have largely been attributed to secondary manifestations of the disease, such as inflammation of the nasal mucosa. Here we show that CFTR, the gene responsible for CF, is expressed in proliferating olfactory human cells and that newborn CFTR null pigs display ultrastructural abnormalities in the olfactory epithelium and olfactory bulbs. In the absence of CFTR, olfactory sensory neurons still produce odor-evoked activity, but mutant animals display defective odor-guided suckling behavior after birth. Consistent with epithelial changes, we found a reduced expression of genes implicated in cell cycle and development in globose basal cells (GBCs), the neurogenic progenitor cells in the olfactory epithelium. Targeted sequencing revealed enhanced CFTR expression in the subpopulation of GBCs that is actively proliferating. Furthermore, CFTR loss caused a global reduction in the number of sensory neurons and altered olfactory receptors expression. Our findings highlight a previously unknown role of CFTR in olfactory system function by regulating progenitor cell proliferation in the olfactory epithelium.

2022-12-31 | GSE197189 | GEO

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