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E-GEOD-53731

ABSTRACT: Expression data from hepatitis E virus inoculated PLC/PRF/5 cells

OTHER RELATED OMICS DATASETS IN: PRJNA232781

PROVIDER: E-GEOD-53731 | ExpressionAtlas | 2015-07-31

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-53731-analysis-methods.tsv	Tabular
	E-GEOD-53731-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-53731-configuration.xml	Xml
	E-GEOD-53731-percentile-ranks.tsv	Tabular
	E-GEOD-53731.condensed-sdrf.tsv	Tabular

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1 - 5 of 23

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Homo sapiens

Project description:Expression data from hepatitis E virus inoculated PLC/PRF/5 cells

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Expression data from hepatitis E virus inoculated PLC/PRF/5 cells

Project description:Hepatitis E virus (HEV) is an important causative pathogen of acute hepatitis. Because of the absence of an in vitro culture system for HEV, research has been greatly impeded. And interaction between HEV and host cells was mainly studied by tansfection/transinfection system, such as Adeno virus transinfection system. We developed an in vitro culture system for HEV in PLC/PRF/5 cells. With this in vitro culture system, we studied the gene expression profile change by HEV infection. Using a microarray assay, we analysed genes of PLC/PRF/5 cells, whose transcription level could be changed by HEV infection. Five flasks of PLC/PRF/5 cells inoculated with HEV were used as test sample, and five flasks inoculated with serum-free DMEM/199 medium were used as control samples. Both test and control flasks were cultured under the same conditions. Sixty days after inoculation, the test and control flasks was resolved with Trizol and analysed with Affymetrix HG-U133 Plus 2 array.

2014-01-01 | E-GEOD-53731 | biostudies-arrayexpress

Manda2019 - Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine response

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Human liver infected by HBV: tumoral part vs non tumoral part of the liver

Project description:Transcriptional profiling comparing tumoral and non tumoral part of human liver infected by hepatitis B virus Expression profiling of induced hepatitis B virus tumor from human liver and expression profiling of hepatitis B virus infected non tumoral part of the liver from french patients Please note that there are 62 raw files (i.e.'AFE_raw_files.tar' linked to the Series records) for 124 samples since two samples were on the same array, one in Cy3 and one in Cy5. The corresponding raw data file for each sample is indicated in the Sample description field. This dataset is part of the TransQST collection.

2013-05-23 | E-GEOD-47197 | biostudies-arrayexpress

The expression of circular RNAs in the plasma from five hepatocellular carcinoma patients and five chronic hepatitis B patients

Project description:Using CapitalBio Technology Human CircRNA Array v2 (4x180K) microarray, we compared the expression of circular RNAs in the plasma from five hepatitis B virus-related hepatocellular carcinoma patients and five chronic hepatitis B patients.

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Homo sapiens

Project description:Expression data from the hepatitis E virus capsid protein

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Sandip2013 - Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin.

Project description:Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin. Banerjee S1, Keval R, Gakkhar S. Author information 1 Department of Mathematics, Indian Institute of Technology Roorkee (IITR), Roorkee 247667, Uttaranchal, India. Electronic address: sandofma@iitr.ernet.in. Abstract A mathematical modeling of hepatitis C virus (HCV) dynamics and antiviral therapy has been presented in this paper. The proposed model, which involves four coupled ordinary differential equations, describes the interaction of target cells (hepatocytes), infected cells, infectious virions and non-infectious virions. The model takes into consideration the addition of ribavirin to interferon therapy and explains the dynamics regarding a biphasic and triphasic decline of viral load in the model. A critical drug efficacy parameter has been defined and it is shown that for an efficacy above this critical value, HCV is eradicated whereas for efficacy lower this critical value, a new steady state for infectious virions is reached, which is lower than the previous steady state value. Copyright © 2013 Elsevier Inc. All rights reserved. KEYWORDS: Hepatitis C virus (HCV); Infected cells; Infectious virions; Interferon; Noninfectious virions; Ribavirin; Target cells

2024-09-02 | BIOMD0000000892 | BioModels

Sandip2013 - Modeling the dynamics of hepatitis C virus with combined antiviral drug therapy: interferon and ribavirin.

2020-01-09 | MODEL1912120002 | BioModels

STOP-HCV_BOSON_HumanGeneticData

Project description:Human genotyping data for patients infected by hepatitis C virus

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Project description:Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions. Gene expression profiling of HCC and non-tumor lesions revealed the predisposing changes of gene expression in HCC. This approach has potential for the early diagnosis and possible prevention of HCC. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. Graphical Gaussian modeling (GGM) was applied to elucidate the interactions of gene clusters among the HCC and non-tumor lesions.

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