Dataset Information

E-MEXP-1192

ABSTRACT: Transcription profiling of human embryonic stem cells treated with BMP4 in chemically-defined medium, with and without inhibitors of Activin and FGF signalling to investigate the induction of extra-embryonic tissue differentiation by BMP signalling

PROVIDER: E-MEXP-1192 | ExpressionAtlas | 2025-01-22

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MEXP-1192-analysis-methods.tsv	Tabular
	E-MEXP-1192-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-1192-configuration.xml	Xml
	E-MEXP-1192-percentile-ranks.tsv	Tabular
	E-MEXP-1192.condensed-sdrf.tsv	Tabular

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Project description:This is the simple model without diffusion described in th epublication Sharp developmental thresholds defined through bistability by antagonistic gradients of retinoic acid and FGF signaling. Goldbeter A, Gonze D, Pourquié O. Dev Dyn. 2007 Jun;236(6):1495-508. PMID: 17497689, doi:10.1016/j.jtbi.2008.01.006 Abstract: The establishment of thresholds along morphogen gradients in the embryo is poorly understood. Using mathematical modeling, we show that mutually inhibitory gradients can generate and position sharp morphogen thresholds in the embryonic space. Taking vertebrate segmentation as a paradigm, we demonstrate that the antagonistic gradients of retinoic acid (RA) and Fibroblast Growth Factor (FGF) along the presomitic mesoderm (PSM) may lead to the coexistence of two stable steady states. Here, we propose that this bistability is associated with abrupt switches in the levels of FGF and RA signaling, which permit the synchronized activation of segmentation genes, such as mesp2, in successive cohorts of PSM cells in response to the segmentation clock, thereby defining the future segments. Bistability resulting from mutual inhibition of RA and FGF provides a molecular mechanism for the all-or-none transitions assumed in the "clock and wavefront" somitogenesis model. Given that mutually antagonistic signaling gradients are common in development, such bistable switches could represent an important principle underlying embryonic patterning. Originally created by libAntimony v1.4 (using libSBML 3.4.1) This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

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E-MEXP-1192

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