Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human embryonic stem cells treated with BMP4 in chemically-defined medium, with and without inhibitors of Activin and FGF signalling to investigate the induction of extra-embryonic tissue differentiation by BMP signalling


ABSTRACT: Gene expression microarray analysis of hESCs treated with BMP4 in chemically-defined medium, with and without inhibitors of Activin and FGF signalling (which maintain pluripotency), to investigate the induction of extra-embryonic tissue (trophectoderm) differentiation by BMP signalling.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Trotter 

PROVIDER: E-MEXP-1192 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways.

Vallier Ludovic L   Touboul Thomas T   Chng Zhenzhi Z   Brimpari Minodora M   Hannan Nicholas N   Millan Enrique E   Smithers Lucy E LE   Trotter Matthew M   Rugg-Gunn Peter P   Weber Anne A   Pedersen Roger A RA  

PloS one 20090630 6


Human embryonic stem cells have unique value for regenerative medicine, as they are capable of differentiating into a broad variety of cell types. Therefore, defining the signalling pathways that control early cell fate decisions of pluripotent stem cells represents a major task. Moreover, modelling the early steps of embryonic development in vitro may provide the best approach to produce cell types with native properties. Here, we analysed the function of key developmental growth factors such a  ...[more]

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