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E-MEXP-3798

ABSTRACT: Transcription profiling by array of Drosophila melanogaster mushroom bodies to gain insight into cellular properties of mushroom body neurons

PROVIDER: E-MEXP-3798 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MEXP-3798-analysis-methods.tsv	Tabular
	E-MEXP-3798-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-3798-configuration.xml	Xml
	E-MEXP-3798-percentile-ranks.tsv	Tabular
	E-MEXP-3798.condensed-sdrf.tsv	Tabular

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Project description:The Drosophila melanogaster mushroom bodies (MBs) are brain structures critical for olfactory memory. The approximately 2000 intrinsic MB neurons are divisible into alpha/beta neurons, alpha'/beta' neurons and gamma neurons by morphology and roles in memory processing. It has also been shown that the different subtypes of MB neurons have different function in the process of memory formation. This difference in function, suggested to us that different types of MB neurons might have different expression profiles. In this study, we used cell-type specific gene expression profiling to gain insight into cellular properties of MB neurons.

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Project description:We report the application of low cell number sequencing of identifiable Drosophila melanogaster neurons following behavior. We demonstate the feasibility of identifying the transcriptome of 5 Mushroom Body output Neurons and 2 classes of Kenyon Cells. We find these neurons display a diverse repertoire of receptors and signaling transcripts. This information alone seems to be enough to identify each class of neurons in the study. In additional we show that aversive long-term memory induces changes in gene transcript levels in a subset of these neurons. This study provides a framework for identifying neuronal classes in Drosophila melanogaster and gaining insight into the interplay between behavior and gene regulation.

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