Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-3382

ABSTRACT: A genetic porcine model of cancer

DISEASE(S): Transgenic Induced Cancer,Normal

PROVIDER: E-MTAB-3382 | ExpressionAtlas | 2019-05-02

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-3382-analysis-methods.tsv	Tabular
	E-MTAB-3382-analytics.tsv	Tabular
	E-MTAB-3382-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-3382-configuration.xml	Xml
	E-MTAB-3382-g1_g2-mvaPlot.png	Other

Items per page:

1 - 5 of 22

Similar Datasets

A genetic porcine model of cancer

Project description:A genetic porcine model of cancer

| PRJEB8735 | ENA

Project description:A Genetic Porcine Model of Cancer

| PRJEB8646 | ENA

Mus musculus

Project description:Genetic Model for Oral Cancer

| PRJNA247825 | ENA

Processed data related to "Gene expression profile of NAFLD murine models" (Part1: E-MTAB-12808, Part2: E-MTAB-12817)

Project description: Not available

| S-BSST1361 | biostudies-other

Sus scrofa

Project description:Invitro Porcine Model Cutaneous Fibrosis

| PRJNA141037 | ENA

CELA1 and AAT deficient murine model proteome

Project description:Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by alpha-1 antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. We tested the role of CELA1 in emphysema development in this genetic model of AAT-deficiency following tracheal lipopolysaccharide (LPS), 10 months of cigarette smoke (CS) exposure, aging, and a low-dose tracheal porcine pancreatic elastase (LD-PPE) model we developed. In this last model, we performed proteomic analysis to understand differences in lung protein composition. We were unable to show that AAT-deficient mice developed more emphysema than wild type with escalating doses of LPS.

2023-02-20 | MSV000091330 | MassIVE

Nimblegen microarrays gene expression analysis of porcine transformed MSCs and sarcomas

Project description:Osteosarcoma is a relatively rare solid tumour, but the most common primary bone cancer. It predominantly affects young people and is highly malignant, requiring aggressive surgical resection and cytotoxic chemotherapy. Five-year survival for patients with metastatic osteosarcoma is only around 30% 14. We report that pigs with heterozygous and homozygous inactivation of TP53 consistently develop osteosarcomas, providing a new model of osteosarcoma at human scale to understand and treat this devastating disease. Gene expression profiling and data analysis was further described in 'A porcine model of osteosarcoma' by Anja Saalfrank et al. (2016). Differential gene expression profiles of MSCs and sarcomas relative to wild type in order to identify transcriptional changes associated with the stages of porcine MSC transformation

2016-02-23 | E-GEOD-78214 | biostudies-arrayexpress

Expression data from Northeastern Indigenous and Large White longissimus dorsi

Project description:To understand the molecular basis of distinct pork quality in Chinese indigenous and Western breed, longissimus dorsi samples were collected from three adult Northeastern Indigenous and from three adult Large White. Total RNA was extracted and subjected to porcine Affymetrix Genechip. The study helps to elucidate the genetic mechnism of divergent pork quality and provide the theory basis for selection and genetic improvement of meat quality traits in porcine.

2016-09-02 | GSE24192 | GEO

Melatonin protects against defects induced by malathion during porcine oocyte maturation

Project description:We used porcine oocytes as model and found that MAL exposure significantly impaired porcine oocyte maturation in a dose dependent manner. RNA-seq analyses showed that MAL altered the mRNA level of 2917 genes in the porcine maturated oocytes and most of these genes were related to ROS, the lipid droplet process and the energy supplement.

2019-06-13 | GSE132618 | GEO

Comparative transcriptomics reveal highly conserved regional programs between porcine and human colonic enteric nervous system

Project description:The enteric nerve system (ENS) coordinates diverse gastrointestinal functions. The porcine gastrointestinal tract is increasingly regarded as a useful translational model. However, porcine ENS molecular profiling and its similarity to that of human are lacking. Bulk RNA sequencing (RNA-seq) coupled with laser-capture microdissection and single-cell RNA-seq on myenteric ganglia (MG) addressed that discrepant transcriptional programs explained the functional characteristics between inner submucosal and/or MG in porcine proximal or/and distal colon (p-pC, p-dC). Comparative bulk transcriptomics of MG in corresponding colonic regions of porcine and human revealed highly conserved programs existing in p-pC and p-dC, which interpreted >90% of their transcriptomic responses to vagal nerve stimulation (VNS), suggesting that p-pC and p-dC could serve as predictors in translational studies. At bulk and single-cell resolution, we highlighted specific conserved programs, executing inflammatory modulation in porcine with VNS. This study offers rich foundations to understand human colonic functions and neuromodulation using porcine model.

2023-01-22 | GSE197106 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data