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E-MTAB-4542

ABSTRACT: Transcription profiling of hearts and kidneys of spontaneously hypertensive rat and coisogenic rat strain with connexin50 mutation

PROVIDER: E-MTAB-4542 | ExpressionAtlas | 2016-03-07

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-4542-analysis-methods.tsv	Tabular
	E-MTAB-4542-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-4542-configuration.xml	Xml
	E-MTAB-4542-percentile-ranks.tsv	Tabular
	E-MTAB-4542.condensed-sdrf.tsv	Tabular

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Project description:We aimed to compare transcriptome in heart and livers of spontaneously hypertensive rat SHR/OlaIpcv (Rat Genome Database ID: 631848) versus coisogenic rat strain SHR-Gja8m1Cub (Rat Genome Database ID: 2293729) using Affymetrix GeneChipÂ® Rat Exon 1.0 ST Arrays in triplicate. Affymetrix GeneChipÂ® Rat Exon 1.0 ST Array was used to determine the transcriptomic characteristics of the SHR and the coisogenic strain SHR-Dca. We extracted total RNA from the kidneys and hearts of 4-month old males of both strains using phenol-chloroform and purified with the RNeasy Mini kit (Qiagen, Valencia, CA, USA) in accordance with the manufacturerâs protocol. The quality of the total RNA was verified by the Agilent 2100 Bioanalyzer system. Double-stranded complementary DNA (cDNA) was synthesized from total RNA. The labeled and fragmented cDNA was pooled for each strain (SHR, SHR-Dca) and tissue (heart, kidney) and hybridized to Affymetrix GeneChipÂ® Rat Exon 1.0 ST Arrays in triplicate (total 12 arrays). The whole hybridization procedure including DNA adjustment was performed according to the protocol recommended by Affymetrix.

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Project description:Ndufc2 gene contributes to stroke susceptibility in the stroke-prone spontaneously hypertensive rat and it associates with juvenile ischemic stroke occurrence in humans

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