Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-3787

ABSTRACT: Transcription profiling of brown adipose tissue from resistin-transgenic spontaneously hypertensive rats

PROVIDER: E-MTAB-3787 | ExpressionAtlas | 2015-08-06

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-3787-analysis-methods.tsv	Tabular
	E-MTAB-3787-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-3787-configuration.xml	Xml
	E-MTAB-3787-percentile-ranks.tsv	Tabular
	E-MTAB-3787.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 52

Similar Datasets

Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue by affecting expression of genes involved in skeletal muscle and connective tissue development, inflammation, MAPK, insulin and calcium signaling.

Project description:Resistin has been originally identified as an adipokine that links obesity to insulin resistance in mice. In our previous studies in spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin (Retn) transgene specifically in adipose tissue (SHR-Retn), we observed an increased lipolysis and serum free fatty acids, ectopic fat accumulation in muscles and insulin resistance. Recently, brown adipose tissue (BAT) has been suggested to play an important role in the pathogenesis of metabolic disturbances by its ability to dissipate energy excess. In the current study, we analyzed autocrine effects of transgenic resistin on BAT glucose and lipid metabolism and mitochondrial function in the SHR-Retn versus nontransgenic SHR controls. We observed that interscapular BAT isolated from SHR-Retn transgenic rats when compared to SHR controls showed a lower relative weight, significantly reduced both basal and insulin stimulated incorporation of palmitate into BAT lipids, and significantly decreased palmitate oxidation and glucose oxidation. In addition, in vivo microPET imaging revealed significantly reduced 18F-FDG uptake in BAT induced by exposure to cold in SHR-Retn versus control SHR. Gene expression profiles identified differentially expressed genes involved in skeletal muscle and connective tissue developmental and inflammation, as well as MAPK and insulin signaling. These results provide compelling evidence that autocrine effects of resisitin in BAT play an important role in the pathogenesis of insulin resistance in the rat.

2016-07-03 | E-MTAB-3787 | biostudies-arrayexpress

E-TABM-418

Project description:Transcription profiling of spontaneously hypertensive heart failure rats (SHHF) and a reference strain to identify heart failure susceptibility genes

2015-11-02 | E-TABM-418 | ExpressionAtlas

E-MTAB-9192

Project description:Mouse interscapular brown, subscapular white and inguinal white adipose tissue

2023-08-04 | E-MTAB-9192 | ExpressionAtlas

E-MTAB-7445

Project description:RNA-seq of age-associated transcriptome changes in brown adipose tissue

2019-01-16 | E-MTAB-7445 | ExpressionAtlas

E-MTAB-8717

Project description:RNA-seq of male and female mouse brown adipose tissue (BAT) transcriptome

2020-07-20 | E-MTAB-8717 | ExpressionAtlas

E-MTAB-7987

Project description:Bulk mRNA-seq of brown adipose tissue derived from SLC25A44 knockdown mouse

2019-09-09 | E-MTAB-7987 | ExpressionAtlas

E-GEOD-2116

Project description:Transcription profiling of rat left ventricular samples from 12-, 16- and 20-month old spontaneously hypertensive rats (SHRs) compared with age-matched Wistar-Kyoto (WKY) rats as controls

2014-08-15 | E-GEOD-2116 | ExpressionAtlas

E-MTAB-4542

Project description:Transcription profiling of hearts and kidneys of spontaneously hypertensive rat and coisogenic rat strain with connexin50 mutation

2016-03-07 | E-MTAB-4542 | ExpressionAtlas

E-MTAB-7561

Project description:RNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet

2020-07-28 | E-MTAB-7561 | ExpressionAtlas

Mutant Cd36 and Wars2 genes affect mass and function of brown adipose tissue in spontaneously hypertensive rats

Project description:Brown adipose tissue (BAT) was suggested to play an important role in lipid and glucose metabolism in rodents and possibly also in humans. In the current study, we used genetic and correlation analyses in the BXH/HXB recombinant inbred (RI) strains, derived from Brown Norway (BN) and spontaneously hypertensive rats (SHR), to identify genetic determinants of BAT function and its role in the pathogenesis of metabolic disturbances. Linkage analyses revealed significant quantitative trait locus (QTL) associated with interscapular BAT mass in the vicinity of the Cd36 (fatty acid translocase) gene on chromosome 4. Additional two closely linked QTL asociated with glucose oxidation and incorporation into BAT lipids were detected near the Wars2 (tryptophanyl tRNA synthetase 2, mitochondrial) candidate gene on chromosome 2.

2017-08-01 | E-MTAB-5292 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data