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E-MTAB-8396

ABSTRACT: Thyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity

PROVIDER: E-MTAB-8396 | ExpressionAtlas | 2023-06-16

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-8396-analysis-methods.tsv	Tabular
	E-MTAB-8396-analytics.tsv	Tabular
	E-MTAB-8396-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-8396-configuration.xml	Xml
	E-MTAB-8396-g1_g2-mvaPlot.png	Other

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Thyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity

Project description:Thyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity

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Thyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity

Project description:This study investigates the development of adipose tissue before birth which is crucial for energy storage and thermogenesis in the neonatal period, and for long term metabolic health. The design uses the thyroid deficiency sheep fetus examined at two different gestational ages.

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Interaction between PPARγ and mTORC1 in the regulation of inguinal white adipose tissue transcriptome

Project description:Purpose: To investigate the involvement of mTORC1 as a mediator of the actions of the PPARγ ligand rosiglitazone in subcutaneous inguinal white adipose tissue transcriptome; Methods: Mice bearing regulatory associated protein of mTOR (Raptor) deletion and therefore mTORC1 deficiency exclusively in adipocytes (adiponectin Cre recombinase) and littermate controls were fed a high-fat diet supplemented or not with the PPARγ agonist rosiglitazone (30 mg/kg/day) for 8 weeks and evaluated for inguinal white adipose tissue transcriptome (Rnaseq); Results: 3,2425 genes had their correspondent mRNA levels altered by either adipocyte Raptor deficiency or rosiglitazone administration or their combination. Among those, 408 genes modulated by rosiglitazone required mTORC1. Conclusion: PPARγ and mTORC1 are essential partners in the regulation of a cluster of genes in inguinal white adipose tissue.

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