Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of white adipose tissue from Lldlr-/- and Lldlr-/-Mif-/- mice

ABSTRACT: MIF deficiency reduces chronic inflammation in white adipose tissue and impairs development of insulin resistance, glucose intolerance and associated atherosclerotic disease

ORGANISM(S): Mus musculus

SUBMITTER: Marjan van Erk

PROVIDER: E-TABM-524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.

Verschuren Lars L Kooistra Teake T Bernhagen Jürgen J Voshol Peter J PJ Ouwens D Margriet DM van Erk Marjan M de Vries-van der Weij Jitske J Leng Lin L van Bockel J Hajo JH van Dijk Ko Willems KW Fingerle-Rowson Günter G Bucala Rick R Kleemann Robert R

Circulation research 20090528 1

Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whether MIF is required for the development of obesity, IR, glucose intolerance, and atherosclerosis in the LDL receptor-deficient (Ldlr(-/-)) mouse model of disease. Ldlr(-/-) mice devel ...[more]

PMID: 19478200

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Dataset Information

Transcription profiling of white adipose tissue from Lldlr-/- and Lldlr-/-Mif-/- mice

Publications

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.

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