Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-8872

ABSTRACT: METTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation

PROVIDER: E-MTAB-8872 | ExpressionAtlas | 2020-12-09

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-8872-analysis-methods.tsv	Tabular
	E-MTAB-8872-analytics.tsv	Tabular
	E-MTAB-8872-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-8872-configuration.xml	Xml
	E-MTAB-8872-g3_g1-mvaPlot.png	Other

Items per page:

1 - 5 of 32

Similar Datasets

Mus musculus

Project description:Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4

| PRJNA103823 | ENA

Targeting Sirt2 reprograms T cell metabolism for effective immune response

Project description:There is a growing evidence that metabolism is a key driver of T cell functions. A switch from oxidative phosphorylation to aerobic glycolysis is a hallmark of T cell activation and is required to meet metabolic demands of proliferation and effector functions. However the mechanisms underlying the metabolic switch in T cells remain unclear. Here we identify Sirt2 as a crucial immune checkpoint coordinating metabolic and functional fitness of T cells. Sirt2 is induced upon T cells activation and increases in late maturation stages. Sirt2 negatively regulates glycolysis by targeting key glycolytic enzymes. Remarkably, Sirt2 knockout T cells exhibit profound upregulation of aerobic glycolysis with enhanced proliferation and effector function and thus effectively reject tumor challenge in vivo. Furthermore pharmacologic inhibition of Sirt2 in human tumor infiltrating lymphocytes demonstrated similar phenotype. Taken together our results demonstrate Sirt2 as an actionable target to reprogram T cell metabolism to augment immunotherapy.

2019-07-24 | ST001373 | MetabolomicsWorkbench

METTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation

Project description:METTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation

| PRJEB37209 | ENA

E-MTAB-7451

Project description:Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism

2021-01-19 | E-MTAB-7451 | ExpressionAtlas

ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth

Project description:ING proteins play an essential role in the control of a variety of cellular functions whose deregulation is associated with tumor formation and dissemination, such as proliferation, apoptosis, senescence or invasion. Accordingly, loss of function of ING proteins is a frequent event in many types of human tumors. In this report, we have studied the function of ING4, a member of the ING family of tumor suppressors, in the context of normal, non-transformed primary fibroblasts. We show that ING4 negatively regulates cell proliferation in this cell type. The antiproliferative action of ING4 requires its ability to recognize chromatin marks, it is p53-dependent and it is lost in an ING4 cancer-associated mutant. Gene expression analysis shows that ING4 regulates the expression and release of soluble factors of the chemokine family. The secretory phenotype regulated by ING4 in primary fibroblasts displays a selective paracrine effect on proliferation, fostering the division of tumor cells, while inhibiting division in primary fibroblasts. Consistently, ING4-expressing fibroblasts promoted tumor growth in vivo in co-injection tumorigenesis assays. Collectively, our results show that ING4 not only can regulate the proliferation of primary non-transformed human fibroblasts, but also orchestrates a secretory phenotype in these cells that promotes tumor cell proliferation in vitro and in vivo. These findings support a critical role for ING4 expression in normal cells in the non-cell autonomous regulation of tumor growth. Gene expression analysis shows that ING4 regulates the expression and release of soluble factors of the chemokine family. Two independent retroviral infections were performed in early pasaje IMR-90 fibroblasts with wild-type ING4 wild type and the N214D mutant. All of them were hibridazed by duplicate againts a reference sample from vector-infected cells

2013-04-22 | E-GEOD-42412 | biostudies-arrayexpress

eIF3 subunit-specific mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

Project description:eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNAeIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual subunits remain poorly defined. Using multi-omic profiling upon acute depletion of eIF3 subunits, we observed that while eIF3a, b, e, and f markedly differed in their impact on eIF3 holo-complex formation and translation, they were each required for cancer cell proliferation and tumor growth. -selective functions of individual subunits remain poorly defined. Using multi-omic profiling upon acute depletion of eIF3 subunits, we observed that while eIF3a, b, e, and f markedly differed in their impact on eIF3 holo-complex formation and translation, they were each required for cancer cell proliferation and tumor growth.

2023-03-14 | PXD034084 | Pride

Gene expression analysis in NB adherent primary cell lines after endothelin-1 treatment

Project description:We cultured adherent primary cell lines from NB tumor samples. Adherent primary cell lines from NB tumor samples have a subpopulation of neural crest progenitors that grow as spheres when cultured in low-binding conditions. We tested the changes in gene expression induced by endothelin-1 (ET1), a cytokine that regulates proliferation, migration, differentiation and survival of NC cells .

2016-02-25 | E-GEOD-78268 | biostudies-arrayexpress

Phase I/II study of prevention of Colorectal Cancer CRC with Allopurinol in High-Risk Subjects

Project description:Primary objectives: The primary endpoint of the study is to estimate the activity of allopurinol compared with placebo on the change in cell proliferation by assessment of Ki-67 Primary endpoints: The primary endpoint of the study is to estimate the activity of allopurinol compared with placebo on the change in cell proliferation by assessment of Ki-67, a biomarker of cell proliferation, in CRC tissue at baseline tumor or polyp biopsy and after 4 weeks of allopurinol treatment surgical resection specimen .

| 2519335 | ecrin-mdr-crc

Endogenous opioid signalling regulates spinal ependymal cell proliferation

Project description:Endogenous opioid signalling regulates spinal ependymal cell proliferation

| PRJNA1076908 | ENA

Project description:GLDN regulates gastric cancer cell proliferation and migration

| PRJNA901382 | ENA