Genomics

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P27 binds to promoters of multiple genes leading to their repression


ABSTRACT: The role of the cyclin-cdk inhibitor p27 in tumorigenesis is still a controversial matter. We demonstrate here that p27 negatively regulates transcription of a number of genes (p27-target genes) involved in key cellular functions as RNA processing, translation, respiration and cell proliferation.

ORGANISM(S): Mus musculus

PROVIDER: GSE20068 | GEO | 2011/12/01

SECONDARY ACCESSION(S): PRJNA129795

REPOSITORIES: GEO

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