Dataset Information

Leloup2003_CircClock_DD_REV-ERBalpha

ABSTRACT: This is model in continous darkness (DD) described in the article Toward a detailed computational model for the mammalian circadian clock This model features the full interlocked negative and positive regulation of Per,Cry,Bmal and REV-ERBalpha. The model exhibits robust oscillations quite independent of the initial conditions for teh parameters given. Each species is assigned zero as initial value, and the graph started at time=120h. Simulation results could be reproduced using Copasi 4.0.19(development) and roadRunner online. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels Team.For more information see the terms of use.To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

SUBMITTER: Enuo He

PROVIDER: BIOMD0000000074 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	BIOMD0000000074?filename=BIOMD0000000074-biopax2.owl	Owl
	BIOMD0000000074?filename=BIOMD0000000074-biopax3.owl	Owl
	BIOMD0000000074?filename=BIOMD0000000074-matlab.m	Other
	BIOMD0000000074?filename=BIOMD0000000074-octave.m	Other
	BIOMD0000000074?filename=BIOMD0000000074.m	Other

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Publications

Toward a detailed computational model for the mammalian circadian clock.

Leloup Jean-Christophe JC Goldbeter Albert A

Proceedings of the National Academy of Sciences of the United States of America 20030529 12

We present a computational model for the mammalian circadian clock based on the intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and Rev-Erb alpha genes. In agreement with experimental observations, the model can give rise to sustained circadian oscillations in continuous darkness, characterized by an antiphase relationship between Per/Cry/Rev-Erbalpha and Bmal1 mRNAs. Sustained oscillations correspond to the rhythms autonomously generated by suprachiasmat ...[more]

PMID: 12775757

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