Ontology highlight
ABSTRACT:
SUBMITTER: Enuo He
PROVIDER: BIOMD0000000078 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 1 - 5 of 16 |
Proceedings of the National Academy of Sciences of the United States of America 20030529 12
We present a computational model for the mammalian circadian clock based on the intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and Rev-Erb alpha genes. In agreement with experimental observations, the model can give rise to sustained circadian oscillations in continuous darkness, characterized by an antiphase relationship between Per/Cry/Rev-Erbalpha and Bmal1 mRNAs. Sustained oscillations correspond to the rhythms autonomously generated by suprachiasmat ...[more]