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Proctor2006_telomere

ABSTRACT: To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Carole Proctor  

PROVIDER: BIOMD0000000087 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
BIOMD0000000087?filename=BIOMD0000000087-biopax2.owl Owl
BIOMD0000000087?filename=BIOMD0000000087-biopax3.owl Owl
BIOMD0000000087?filename=BIOMD0000000087-matlab.m Other
BIOMD0000000087?filename=BIOMD0000000087-octave.m Other
BIOMD0000000087?filename=BIOMD0000000087.m Other
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Publications

Modelling the checkpoint response to telomere uncapping in budding yeast.

Proctor C J CJ   Lydall D A DA   Boys R J RJ   Gillespie C S CS   Shanley D P DP   Wilkinson D J DJ   Kirkwood T B L TB  

Journal of the Royal Society, Interface 20070201 12

One of the DNA damage-response mechanisms in budding yeast is temporary cell-cycle arrest while DNA repair takes place. The DNA damage response requires the coordinated interaction between DNA repair and checkpoint pathways. Telomeres of budding yeast are capped by the Cdc13 complex. In the temperature-sensitive cdc13-1 strain, telomeres are unprotected over a specific temperature range leading to activation of the DNA damage response and subsequently cell-cycle arrest. Inactivation of cdc13-1 r  ...[more]

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