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Fernandez2006_ModelB

ABSTRACT: To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Nicolas Le Novère  

PROVIDER: BIOMD0000000153 | BioModels | 2024-09-02

REPOSITORIES: BioModels

Json Xml

Dataset's files

Source:
Action DRS
BIOMD0000000153?filename=BIOMD0000000153-biopax2.owl Owl
BIOMD0000000153?filename=BIOMD0000000153-biopax3.owl Owl
BIOMD0000000153?filename=BIOMD0000000153-matlab.m Other
BIOMD0000000153?filename=BIOMD0000000153-octave.m Other
BIOMD0000000153?filename=BIOMD0000000153.m Other
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Publications

DARPP-32 is a robust integrator of dopamine and glutamate signals.

Fernandez Eric E   Schiappa Renaud R   Girault Jean-Antoine JA   Le Novère Nicolas N  

PLoS computational biology 20061106 12

Integration of neurotransmitter and neuromodulator signals in the striatum plays a central role in the functions and dysfunctions of the basal ganglia. DARPP-32 is a key actor of this integration in the GABAergic medium-size spiny neurons, in particular in response to dopamine and glutamate. When phosphorylated by cAMP-dependent protein kinase (PKA), DARPP-32 inhibits protein phosphatase-1 (PP1), whereas when phosphorylated by cyclin-dependent kinase 5 (CDK5) it inhibits PKA. DARPP-32 is also re  ...[more]

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