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Legewie2006_apoptosis_WT

ABSTRACT: The model reproduces active Caspase-3 time profile corresponding to the total Apaf-1 value of 20 nM as depicted in Fig 2-A . The model was successfully tested on MathSBML.

SUBMITTER: Nicolas Le Novère

PROVIDER: BIOMD0000000102 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000102?filename=BIOMD0000000102-biopax2.owl	Owl
	BIOMD0000000102?filename=BIOMD0000000102-biopax3.owl	Owl
	BIOMD0000000102?filename=BIOMD0000000102-matlab.m	Other
	BIOMD0000000102?filename=BIOMD0000000102-octave.m	Other
	BIOMD0000000102?filename=BIOMD0000000102.m	Other

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Publications

Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability.

Legewie Stefan S Blüthgen Nils N Herzel Hanspeter H

PLoS computational biology 20060728 9

The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis induction by various stimuli including cytotoxic stress. It depends on the cellular context, whether cytochrome c released from mitochondria induces caspase activation gradually or in an all-or-none fashion, and whether caspase activation irreversibly commits cells to apoptosis. By analyzing a quantitative kinetic model, we show that inhibition of caspase-3 (Casp3) and Casp9 by inhibitors of apoptosis (IAPs ...[more]

PMID: 16978046

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