Ontology highlight
ABSTRACT:
SUBMITTER: Kilian Bartholomé
PROVIDER: BIOMD0000000197 | BioModels | 2024-09-02
REPOSITORIES: BioModels
Items per page: 1 - 5 of 11 |
Drug metabolism and disposition: the biological fate of chemicals 20070604 9
Vectorial transport of endogenous small molecules, toxins, and drugs across polarized epithelial cells contributes to their half-life in the organism and to detoxification. To study vectorial transport in a quantitative manner, an in vitro model was used that includes polarized MDCKII cells stably expressing the recombinant human uptake transporter OATP1B3 in their basolateral membrane and the recombinant ATP-driven efflux pump ABCC2 in their apical membrane. These double-transfected cells enabl ...[more]