Dataset Information

Cooper2015 - Modeling the effects of systemic mediators on the inflammatory phase of wound healing

ABSTRACT: This is an ordinary differential equation-based mathematical model describing the inflammatory phase of the wound healing response. The model describes the interactions in the wound between wound debris, pathogens, neutrophils and macrophages, as well as the modulation of these interactions by estrogen and cortisol.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000855 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000855?filename=Cooper2015.cps	Other
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Modeling the effects of systemic mediators on the inflammatory phase of wound healing.

Cooper Racheal L RL Segal Rebecca A RA Diegelmann Robert F RF Reynolds Angela M AM

Journal of theoretical biology 20141120

The normal wound healing response is characterized by a progression from clot formation, to an inflammatory phase, to a repair phase, and finally, to remodeling. In many chronic wounds there is an extended inflammatory phase that stops this progression. In order to understand the inflammatory phase in more detail, we developed an ordinary differential equation model that accounts for two systemic mediators that are known to modulate this phase, estrogen (a protective hormone during wound healing ...[more]

PMID: 25446708

Publication: 1/4

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