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Liu2012 - Genome-scale metabolic network of Scheffersomyces stipitis (iTL885)


ABSTRACT: Liu2012 - Genome-scale metabolic network of Scheffersomyces stipitis (iTL885) This model is described in the article: A constraint-based model of Scheffersomyces stipitis for improved ethanol production. Liu T, Zou W, Liu L, Chen J. Biotechnol Biofuels 2012; 5(1): 72 Abstract: UNLABELLED: BACKGROUND: As one of the best xylose utilization microorganisms, Scheffersomyces stipitis exhibits great potential for the efficient lignocellulosic biomass fermentation. Therefore, a comprehensive understanding of its unique physiological and metabolic characteristics is required to further improve its performance on cellulosic ethanol production. RESULTS: A constraint-based genome-scale metabolic model for S. stipitis CBS 6054 was developed on the basis of its genomic, transcriptomic and literature information. The model iTL885 consists of 885 genes, 870 metabolites, and 1240 reactions. During the reconstruction process, 36 putative sugar transporters were reannotated and the metabolisms of 7 sugars were illuminated. Essentiality study was conducted to predict essential genes on different growth media. Key factors affecting cell growth and ethanol formation were investigated by the use of constraint-based analysis. Furthermore, the uptake systems and metabolic routes of xylose were elucidated, and the optimization strategies for the overproduction of ethanol were proposed from both genetic and environmental perspectives. CONCLUSIONS: Systems biology modelling has proven to be a powerful tool for targeting metabolic changes. Thus, this systematic investigation of the metabolism of S. stipitis could be used as a starting point for future experiment designs aimed at identifying the metabolic bottlenecks of this important yeast. This model is hosted on BioModels Database and identified by: MODEL1507180026. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Nicolas Le Novère  

PROVIDER: MODEL1507180026 | BioModels | 2015-07-30

REPOSITORIES: BioModels

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A constraint-based model of Scheffersomyces stipitis for improved ethanol production.

Liu Ting T   Zou Wei W   Liu Liming L   Chen Jian J  

Biotechnology for biofuels 20120921 1


<h4>Unlabelled</h4><h4>Background</h4>As one of the best xylose utilization microorganisms, Scheffersomyces stipitis exhibits great potential for the efficient lignocellulosic biomass fermentation. Therefore, a comprehensive understanding of its unique physiological and metabolic characteristics is required to further improve its performance on cellulosic ethanol production.<h4>Results</h4>A constraint-based genome-scale metabolic model for S. stipitis CBS 6054 was developed on the basis of its  ...[more]

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