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Perrett2014 - GnRH pulse, ERK activity

ABSTRACT: No description

SUBMITTER: Margaritis Voliotis

PROVIDER: MODEL1509050002 | BioModels | 2016-02-10

REPOSITORIES: BioModels

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Publications

Pulsatile hormonal signaling to extracellular signal-regulated kinase: exploring system sensitivity to gonadotropin-releasing hormone pulse frequency and width.

Perrett Rebecca M RM Voliotis Margaritis M Armstrong Stephen P SP Fowkes Robert C RC Pope George R GR Tsaneva-Atanasova Krasimira K McArdle Craig A CA

The Journal of biological chemistry 20140130 11

Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction. It acts via G-protein-coupled receptors to stimulate effectors, including ERK. Information could be encoded in GnRH pulse frequency, width, amplitude, or other features of pulse shape, but the relative importance of these features is unknown. Here we examine this using automated fluorescence microscopy and mathema ...[more]

PMID: 24482225

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