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Bekkar2018 - MAPK1-3 regulation in atherosclerosis

ABSTRACT: This network was obtained by combining (with an OR logical operator) the following list of MAPK1_3 activators: PDGFRB - reference in pubmed:19742316 PDGFB AND (NOT glyoxal) - reference in pubmed:17504976 PARP1 - reference in pubmed:23770291 LEP - reference in pubmed:9815153 PDGFB AND (NOT methylglyoxal) - reference in pubmed:17504976 oxLDL - reference in pubmed:19176597 IL1B_secretion - reference in pubmed:19727662

SUBMITTER: Amel Bekkar

PROVIDER: MODEL1712240003 | BioModels | 2018-11-16

REPOSITORIES: BioModels

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	MODEL1712240003?filename=Bekkar2017_MAPK1-3_regulation_atherosclerosis.sbml	Other

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Publications

Expert curation for building network-based dynamical models: a case study on atherosclerotic plaque formation.

Bekkar Amel A Estreicher Anne A Niknejad Anne A Casals-Casas Cristina C Bridge Alan A Xenarios Ioannis I Dorier Julien J Crespo Isaac I

Database : the journal of biological databases and curation 20180101

<h4>Database url</h4>http://biomodels.caltech.edu. ...[more]

PMID: 29688381

Publication: 1/7

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Bekkar2018 - PPARA regulation in atherosclerosis

Project description:This network was obtained by combining (with an OR logical operator) the following list of PPARA activators: SIRT1 AND PPARGC1A - reference in pubmed:23770291 (NOT MAPK14) AND PPARGC1A - reference in pubmed:24744784 SIRT1 - reference in pubmed:23770291 PPARGC1A - reference in pubmed:23223635 TNF AND PPARGC1A - reference in pubmed:23223635

2018-11-16 | MODEL1712240001 | BioModels

Bekkar2018 - IL1B secretion and regulation in atherosclerosis

Project description:This network was obtained by combining (with an OR logical operator) the following list of IL1B_secretion activators: TXNIP AND IL1B - reference in pubmed:23747245 IL1B AND hydrogen_peroxide - reference in pubmed:20023662 NLRP3_PYCARD_CASP1_complex AND IL1B AND cholesterol_crystal - reference in pubmed:23747245 IL1B AND NLRP3 AND hydrogen_peroxide - reference in pubmed:20023662 IL1B AND oxLDL AND TLR4 - reference in pubmed:23812099 IL1B AND glucose - reference in pubmed:20023662 IL1B AND IL1B_secretion - reference in pubmed:23747245 IL1B AND CASP8 - reference in pubmed:22365665 NLRP3_PYCARD_CASP1_complex AND NFE2L2 AND IL1B - reference in pubmed:23747245 PYCARD AND IL1B AND hydrogen_peroxide - reference in pubmed:20023662 IL1B AND NLRP3 AND glucose - reference in pubmed:20023662 NFE2L2 AND IL1B - reference in pubmed:23747245 IL1B AND mitochondrial_respiratory_chain_complex_I - reference in pubmed:21124315 TXNIP AND IL1B AND glucose - reference in pubmed:20023662 IL1B AND oxLDL AND CD36 - reference in pubmed:23812099 IL1B AND ripoptosome - reference in pubmed:22365665 NLRP3_PYCARD_CASP1_complex AND IL1B - reference in pubmed:23747245

2018-11-16 | MODEL1712240002 | BioModels

Effects of daf-2 mutation, dietary restriction and age on C.elegans proteome

Project description:The overarching project goal was to describe proteome differences between long- and normal-living C.elegans worms. The associated publications are http://www.ncbi.nlm.nih.gov/pubmed/24555535 http://www.ncbi.nlm.nih.gov/pubmed/24002365

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Comparing the transcriptome of naïve C57BL/6 CD44+/+ vs CD44-/- alveolar macrophages

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Gastric Cancer Study GC_126

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Project description:Atherosclerosis and its attendant clinical complications, such as myocardial infarction, stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in Western societies. In response to biochemical and biomechanical stimuli, atherosclerotic lesion formation occurs from the participation of a range of cell types, inflammatory mediators, and shear stress. Over the past decade, microRNAs (miRNAs) have emerged as evolutionarily conserved, noncoding small RNAs that serve as important regulators and fine-tuners of a range of pathophysiological cellular effects and molecular signaling pathways involved in atherosclerosis. Accumulating studies reveal the importance of miRNAs in regulating key signaling and lipid homeostasis pathways that alter the balance of atherosclerotic plaque progression and regression. In this review, we highlight current paradigms of miRNA-mediated effects in atherosclerosis progression and regression. We provide an update on the potential use of miRNAs diagnostically for detecting increasing severity of coronary disease and clinical events. Finally, we provide a perspective on therapeutic opportunities and challenges for miRNA delivery in the field.

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Normal_human_tissues

Project description:Array hybridizations profiling diverse human tissues; for each array the human tissue RNA is hybridized against a universal reference RNA. Series_type: Logical set Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: other

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