Proteomics

Dataset Information

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Effects of daf-2 mutation, dietary restriction and age on C.elegans proteome

ABSTRACT: The overarching project goal was to describe proteome differences between long- and normal-living C.elegans worms. The associated publications are http://www.ncbi.nlm.nih.gov/pubmed/24555535 http://www.ncbi.nlm.nih.gov/pubmed/24002365

REANALYSED by: PAe005606PAe005590PAe005589PAe005575PAe005571PAe005567PAe005565PAe005563

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Vlad Petyuk  

LAB HEAD: Vladislav Petyuk

PROVIDER: PXD002161 | Pride | 2015-05-13

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
c_elegans_A_3_1_21Apr10_Draco_10-03-04.RAW Raw
c_elegans_A_3_1_21Apr10_Draco_10-03-04.mzML.gz Mzml
c_elegans_A_3_1_21Apr10_Draco_10-03-04.pride.mgf.gz Mgf
c_elegans_A_3_1_21Apr10_Draco_10-03-04_msgfplus.mzid.gz Mzid
c_elegans_A_3_1_21Apr10_Draco_10-03-04_msgfplus.pride.mztab.gz Mztab
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Publications

Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.

Depuydt Geert G   Xie Fang F   Petyuk Vladislav A VA   Shanmugam Nilesh N   Smolders Arne A   Dhondt Ineke I   Brewer Heather M HM   Camp David G DG   Smith Richard D RD   Braeckman Bart P BP  

Molecular & cellular proteomics : MCP 20130903 12

Reduced signaling through the C. elegans insulin/insulin-like growth factor-1-like tyrosine kinase receptor daf-2 and dietary restriction via bacterial dilution are two well-characterized lifespan-extending interventions that operate in parallel or through (partially) independent mechanisms. Using accurate mass and time tag LC-MS/MS quantitative proteomics, we detected that the abundance of a large number of ribosomal subunits is decreased in response to dietary restriction, as well as in the da  ...[more]

PMID: 24002365

Publication: 1/2

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