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Mitrophanov2014 - Extended Hockin Blood Coagulation Model with additional fibrin-associated species

ABSTRACT: Mathematical model of the blood coagulation cascade. Extended Hockin model with contributions from Kim2007, Naski1991, Schneider2004, Horrevoets1996, Brummel-Ziedins2012, Mitrophanov2012, Danforth2009 and Hekman1988. Model incorporates more fibrin associated species such as fibrin I and II monomers and fibrinopeptide A and B as well as factor V fragments.

SUBMITTER: Matthew Roberts

PROVIDER: MODEL1806260001 | BioModels | 2018-06-26

REPOSITORIES: BioModels

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	MODEL1806260001?filename=Mitrophanov2014.cps	Other
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	MODEL1806260001?filename=figS2.pdf	Pdf

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Publications

Kinetic model facilitates analysis of fibrin generation and its modulation by clotting factors: implications for hemostasis-enhancing therapies.

Mitrophanov Alexander Y AY Wolberg Alisa S AS Reifman Jaques J

Molecular bioSystems 20140701 9

Current mechanistic knowledge of protein interactions driving blood coagulation has come largely from experiments with simple synthetic systems, which only partially represent the molecular composition of human blood plasma. Here, we investigate the ability of the suggested molecular mechanisms to account for fibrin generation and degradation kinetics in diverse, physiologically relevant in vitro systems. We represented the protein interaction network responsible for thrombin generation, fibrin ...[more]

PMID: 24958246

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