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Rojano2019 - Blood Coagulation Model


ABSTRACT: Blood coagulation mathematical model derived from Chatterjee et al. (2010) and Hockin et al. (2002). Included various inhibitors: TFPI, ATIII, generic kallikrein inhibitor, C1-inhibitor, alpha1-antitrypsin and alpha2-antiplasmin.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1907120001 | BioModels | 2019-07-12

REPOSITORIES: BioModels

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Publications

Kinetics of the coagulation cascade including the contact activation system: sensitivity analysis and model reduction.

Méndez Rojano Rodrigo R   Mendez Simon S   Lucor Didier D   Ranc Alexandre A   Giansily-Blaizot Muriel M   Schved Jean-François JF   Nicoud Franck F  

Biomechanics and modeling in mechanobiology 20190321 4


Thrombus formation is one of the main issues in the development of blood-contacting medical devices. This article focuses on the modeling of one aspect of thrombosis, the coagulation cascade, which is initiated by the contact activation at the device surface and forms thrombin. Models exist representing the coagulation cascade by a series of reactions, usually solved in quiescent plasma. However, large parameter uncertainty involved in the kinetic models can affect the predictive capabilities of  ...[more]

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