Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1907120001 | BioModels | 2019-07-12
REPOSITORIES: BioModels
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MODEL1907120001?filename=Rojano2019.cps | Other |
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Méndez Rojano Rodrigo R Mendez Simon S Lucor Didier D Ranc Alexandre A Giansily-Blaizot Muriel M Schved Jean-François JF Nicoud Franck F
Biomechanics and modeling in mechanobiology 20190321 4
Thrombus formation is one of the main issues in the development of blood-contacting medical devices. This article focuses on the modeling of one aspect of thrombosis, the coagulation cascade, which is initiated by the contact activation at the device surface and forms thrombin. Models exist representing the coagulation cascade by a series of reactions, usually solved in quiescent plasma. However, large parameter uncertainty involved in the kinetic models can affect the predictive capabilities of ...[more]