Floc'hlay2020 - SeaUrchin_model_ginsim
Ontology highlight
ABSTRACT:
SUBMITTER: 
Denis Thieffry
PROVIDER: MODEL2002190001 | BioModels | 2021-01-06
REPOSITORIES: BioModels
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MODEL2002190001?filename=SeaUrchin_model_ginsim.sbml | Other |
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Publications
Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo.
Floc'hlay Swann S Molina Maria Dolores MD Hernandez Céline C Haillot Emmanuel E Thomas-Chollier Morgane M Lepage Thierry T Thieffry Denis D
Development (Cambridge, England) 20210120 2
During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral organiser region specifies the ventral and dorsal territories. This process relies on a complex interplay between the Nodal and BMP pathways through numerous regulatory circuits. To decipher the interplay between these pathways, we used a combination of treatments with recombinant Nodal and BMP2/4 proteins and a computational modelling approach. We assembled a logical model ...[more]
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