Dataset Information

Mbodj2016 - Mesoderm specification during Drosophila development

ABSTRACT: Mbodj2016 - Mesoderm specification during Drosophila development This model is described in the article: Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes. Mbodj A, Gustafson EH, Ciglar L, Junion G, Gonzalez A, Girardot C, Perrin L, Furlong EE, Thieffry D. PLoS Comput. Biol. 2016 Sep; 12(9): e1005073 Abstract: Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate highly interconnected pathways with ample cross-talk. Here, we delineate a logical model encompassing 48 components and 82 regulatory interactions involved in mesoderm specification during Drosophila development, thereby providing a formal integration of all available genetic information from the literature. The four main tissues derived from mesoderm correspond to alternative stable states. We demonstrate that the model can predict known mutant phenotypes and use it to systematically predict the effects of over 300 new, often non-intuitive, loss- and gain-of-function mutations, and combinations thereof. We further validated several novel predictions experimentally, thereby demonstrating the robustness of model. Logical modelling can thus contribute to formally explain and predict regulatory outcomes underlying cell fate decisions. This model is hosted on BioModels Database and identified by: MODEL1607310000. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Denis Thieffry

PROVIDER: MODEL1607310000 | BioModels | 2016-10-25

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1607310000?filename=MODEL1607310000-biopax2.owl	Owl
	MODEL1607310000?filename=MODEL1607310000-biopax3.owl	Owl
	MODEL1607310000?filename=MODEL1607310000.m	Other
	MODEL1607310000?filename=MODEL1607310000.pdf	Pdf
	MODEL1607310000?filename=MODEL1607310000.png	Other

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Publications

Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes.

Mbodj Abibatou A Gustafson E Hilary EH Ciglar Lucia L Junion Guillaume G Gonzalez Aitor A Girardot Charles C Perrin Laurent L Furlong Eileen E M EE Thieffry Denis D

PLoS computational biology 20160906 9

Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate highly interconnected pathways with ample cross-talk. Here, we delineate a logical model encompassing 48 components and 82 regulatory interactions involved in mesoderm specification during Drosophila development, thereby providing a formal integration o ...[more]

PMID: 27599298

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