Ontology highlight
ABSTRACT:
SUBMITTER: Erzsébet Ravasz Regan
PROVIDER: MODEL2312140001 | BioModels | 2024-08-26
REPOSITORIES: BioModels
Sizek Herbert H Deritei Dávid D Fleig Katherine K Harris Marlayna M Regan Peter L PL Glass Kimberly K Regan Erzsébet Ravasz ER
Translational oncology 20240819
The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome, including cytokines, growth and transforming signals. Yet, the physiological triggers of senescence such as reactive oxygen species (ROS) can also trigger mitochondrial dysfunction, and sufficient energy deficit to alter their secretome and cause chro ...[more]