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Koch2021 - Phospholamban_network

ABSTRACT: Ordinary differential equation model of the micropeptide phospholamban and the control of its phosphorylation status at serine 16 in the context of beta-adrenergic stimulation. This model is the first detailed kinetic model of the phospholamban subnetwork of the beta-adrenergic signaling pathway and (to the authors' knowledge) the very first to include phospholamban pentamers. Simulations and model analyses reveal interesting nonlinear dynamics (response delays) and steady-state behavior (bistability) which could serve as molecular noise-filters to prevent the occurence of cardiac arrhythmias.

SUBMITTER: Daniel Koch

PROVIDER: MODEL2011110001 | BioModels | 2021-07-19

REPOSITORIES: BioModels

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			Action	DRS
	MODEL2011110001?filename=FRA_clean.m	Other
	MODEL2011110001?filename=PLN_model.m	Other
	MODEL2011110001?filename=README.txt	Txt
	MODEL2011110001?filename=Simulations_v1_1_clean.m	Other

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