Haiman2020 - Full Kinase Regulatory Model of Erythrocyte Glycolysis

ABSTRACT: Dynamic model utilizing mass action kinetics to elucidate network-level effects of allosteric regulation in erythrocyte metabolism. The full kinase regulatory model includes the glycolytic pathway, the Rapaport Leubering (R.L.) Shunt, hemoglobin-oxygen binding, and elementary reaction steps to represent the enzymatic mechanisms for Hexokinase (HEX1), Phosphofructokinase (PFK), and Pyruvate Kinase (PYK). The model and its variations are assembled using the MASSpy software through a module-wise building process outlined in Yurkovich et. al (2018). To validate the MASSpy modeling tool, select results presented in Yurkovich et. al (2018) are reproduced. All models associated with the validation example of the MASSpy publication are additionally hosted at (https://github.com/SBRG/MASSpy-publication), including iPython notebooks to construct all model variations presented in the publication. The MASSpy validation example reproduces models and results from the following publication: Yurkovich JT, Alcantar MA, Haiman ZB, Palsson BO (2018) Network-level allosteric effects are elucidated by detailing how ligand-binding events modulate utilization of catalytic potentials. PLOS Computational Biology 14(8): e1006356. https://doi.org/10.1371/journal.pcbi.1006356

SUBMITTER: Zack Haiman  

PROVIDER: MODEL2012150001 | BioModels | 2024-10-09

REPOSITORIES: BioModels