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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Mycobacterium tuberculosis after treatment with ciprofloxacin to investigate the SOS DNA repair response

ABSTRACT: Data is also available from http://bugs.sgul.ac.uk/E-BUGS-63

INSTRUMENT(S): Variable Atmosphere Incubator, Bioanalyser

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER:

PROVIDER: E-BUGS-63 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mycobacterium tuberculosis DNA repair in response to subinhibitory concentrations of ciprofloxacin.

O'Sullivan D M DM Hinds J J Butcher P D PD Gillespie S H SH McHugh T D TD

The Journal of antimicrobial chemotherapy 20080916 6

<h4>Objectives</h4>To investigate how the SOS response, an error-prone DNA repair pathway, is expressed following subinhibitory quinolone treatment of Mycobacterium tuberculosis.<h4>Methods</h4>Genome-wide expression profiling followed by quantitative RT (qRT)-PCR was used to study the effect of ciprofloxacin on M. tuberculosis gene expression.<h4>Results</h4>Microarray analysis showed that 16/110 genes involved in DNA protection, repair and recombination were up-regulated. There appeared to be ...[more]

PMID: 18799471

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