Ontology highlight
ABSTRACT:
INSTRUMENT(S): Nanodrop N1000 spectrophotometer
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER:
PROVIDER: E-BUGS-80 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Makarov Vadim V Manina Giulia G Mikusova Katarina K Möllmann Ute U Ryabova Olga O Saint-Joanis Brigitte B Dhar Neeraj N Pasca Maria Rosalia MR Buroni Silvia S Lucarelli Anna Paola AP Milano Anna A De Rossi Edda E Belanova Martina M Bobovska Adela A Dianiskova Petronela P Kordulakova Jana J Sala Claudia C Fullam Elizabeth E Schneider Patricia P McKinney John D JD Brodin Priscille P Christophe Thierry T Waddell Simon S Butcher Philip P Albrethsen Jakob J Rosenkrands Ida I Brosch Roland R Nandi Vrinda V Bharath Sowmya S Gaonkar Sheshagiri S Shandil Radha K RK Balasubramanian Venkataraman V Balganesh Tanjore T Tyagi Sandeep S Grosset Jacques J Riccardi Giovanna G Cole Stewart T ST
Science (New York, N.Y.) 20090319 5928
New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB. Using genetics and biochemistry, we identified the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase as a major BTZ target. Inhibition of this enzymatic activity abolishes the formation of decaprenylphosphoryl arabinos ...[more]