Ontology highlight
ABSTRACT:
INSTRUMENT(S): Affymetrix Fluidics Station 400
ORGANISM(S): Mus musculus
SUBMITTER: Gerard Gradwohl
PROVIDER: E-CBIL-48 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Development (Cambridge, England) 20100101 2
The transcription factor neurogenin 3 (Neurog3 or Ngn3) controls islet cell fate specification in multipotent pancreatic progenitor cells in the mouse embryo. However, our knowledge of the genetic programs implemented by Ngn3, which control generic and islet subtype-specific properties, is still fragmentary. Gene expression profiling in isolated Ngn3-positive progenitor cells resulted in the identification of the uncharacterized winged helix transcription factor Rfx6. Rfx6 is initially expressed ...[more]