Proteomics

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Proteomic analysis of acute pancreatitis in TRP14-KO miceProteomic analysis of acute pancreatitis in TRP14-KO mice


ABSTRACT: We have studied pancreas samples in pancreas from a mouse model of acute pancreatitis, comparing wild-type animals and TRP14 KO animals. Samples are extracted with N-ethylmaleimide to block reduced cysteines, and no reducing agent is used, with a search including cysteinylated peptides. Acute pancreatitis was induced in 12 weeks-old mice (wild-type and KO for TRP14) by seven intraperitoneal injections of cerulein (50 µg/kg body weight) at 1 h intervals. Then, 1 h after the last injection, animals were euthanized under anesthesia with 3% isoflurane, exsanguinated, and the pancreas was immediately removed and processed.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreas

DISEASE(S): Acute Pancreatitis

SUBMITTER: Antonio Martínez Ruiz  

LAB HEAD: Antonio Martínez-Ruiz

PROVIDER: PXD050765 | Pride | 2024-05-15

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
070621_JSastre_ED_WTS_1.mgf Mgf
070621_JSastre_ED_WTS_1.raw Raw
070621_JSastre_ED_WTS_2.mgf Mgf
070621_JSastre_ED_WTS_2.raw Raw
070621_JSastre_ED_WTS_3.mgf Mgf
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