Molecular profiles (HG-U95A) of dystrophin-deficient and normal human muscle
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Judith Haslett
PROVIDER: E-GEOD-1004 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle.
Haslett Judith N JN Sanoudou Despina D Kho Alvin T AT Bennett Richard R RR Greenberg Steven A SA Kohane Isaac S IS Beggs Alan H AH Kunkel Louis M LM
Proceedings of the National Academy of Sciences of the United States of America 20021101 23
The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and protein. Absence of dystrophin leads to disruption of the dystrophin-associated protein complex and substantial changes in skeletal muscle pathology. Although the histological pathology of dystrophic tissue has been well documented, the underlying molecular pathways remain poorly understood. To examine the pathogenic pathways and identify new ...[more]
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