Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Christina Yau
PROVIDER: E-GEOD-10061 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yau Christina C Benz Christopher C CC
Breast cancer research : BCR 20080717 4
<h4>Introduction</h4>Oxidative stress can modify estrogen receptor (ER) structure and function, including induction of progesterone receptor (PR), altering the biology and clinical behavior of endocrine responsive (ER-positive) breast cancer.<h4>Methods</h4>To investigate the impact of oxidative stress on estrogen/ER-regulated gene expression, RNA was extracted from ER-positive/PR-positive MCF7 breast cancer cells after 72 hours of estrogen deprivation, small-interfering RNA knockdown of ER-alph ...[more]